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使用治疗期间获得的整合图像进行 VMAT 适形调强治疗的剂量学验证。

Portal dosimetry for VMAT using integrated images obtained during treatment.

机构信息

Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom.

出版信息

Med Phys. 2014 Feb;41(2):021725. doi: 10.1118/1.4862515.

Abstract

PURPOSE

Portal dosimetry provides an accurate and convenient means of verifying dose delivered to the patient. A simple method for carrying out portal dosimetry for volumetric modulated arc therapy (VMAT) is described, together with phantom measurements demonstrating the validity of the approach.

METHODS

Portal images were predicted by projecting dose in the isocentric plane through to the portal image plane, with exponential attenuation and convolution with a double-Gaussian scatter function. Appropriate parameters for the projection were selected by fitting the calculation model to portal images measured on an iViewGT portal imager (Elekta AB, Stockholm, Sweden) for a variety of phantom thicknesses and field sizes. This model was then used to predict the portal image resulting from each control point of a VMAT arc. Finally, all these control point images were summed to predict the overall integrated portal image for the whole arc. The calculated and measured integrated portal images were compared for three lung and three esophagus plans delivered to a thorax phantom, and three prostate plans delivered to a homogeneous phantom, using a gamma index for 3% and 3 mm. A 0.6 cm(3) ionization chamber was used to verify the planned isocentric dose. The sensitivity of this method to errors in monitor units, field shaping, gantry angle, and phantom position was also evaluated by means of computer simulations.

RESULTS

The calculation model for portal dose prediction was able to accurately compute the portal images due to simple square fields delivered to solid water phantoms. The integrated images of VMAT treatments delivered to phantoms were also correctly predicted by the method. The proportion of the images with a gamma index of less than unity was 93.7% ± 3.0% (1SD) and the difference between isocenter dose calculated by the planning system and measured by the ionization chamber was 0.8% ± 1.0%. The method was highly sensitive to errors in monitor units and field shape, but less sensitive to errors in gantry angle or phantom position.

CONCLUSIONS

This method of predicting integrated portal images provides a convenient means of verifying dose delivered using VMAT, with minimal image acquisition and data processing requirements.

摘要

目的

门控剂量验证为验证患者所接受的剂量提供了一种准确且方便的方法。本文描述了一种用于容积旋转调强放疗(VMAT)的门控剂量验证的简单方法,并通过体模测量验证了该方法的有效性。

方法

通过将等中心平面的剂量投影到门控图像平面上,同时进行指数衰减和双高斯散射函数卷积,来预测门控图像。通过将计算模型拟合到在 iViewGT 门控成像仪(瑞典斯德哥尔摩 Elekta AB)上测量的各种体模厚度和射野大小的门控图像,选择合适的投影参数。然后,使用该模型来预测 VMAT 弧形的每个控制点产生的门控图像。最后,将所有这些控制点图像相加,以预测整个弧形的整体积分门控图像。将计算和测量的积分门控图像进行比较,比较对象为三个肺部和三个食管计划在胸部体模中的治疗结果,以及三个前列腺计划在均匀体模中的治疗结果,使用 3%和 3mm 的伽玛指数进行比较。使用 0.6cm3 的电离室验证计划的等中心剂量。通过计算机模拟评估了该方法对 MU、射野成型、机架角度和体模位置误差的敏感性。

结果

门控剂量预测的计算模型能够准确计算出在实心水模体上简单方形射野照射的门控图像。通过该方法还可以正确预测体模中 VMAT 治疗的积分图像。伽玛指数小于 1 的图像比例为 93.7%±3.0%(1SD),计划系统计算的等中心剂量与电离室测量的剂量之间的差异为 0.8%±1.0%。该方法对 MU 和射野形状误差非常敏感,但对机架角度或体模位置误差不太敏感。

结论

这种预测积分门控图像的方法为使用 VMAT 验证剂量提供了一种方便的方法,只需进行最小的图像采集和数据处理。

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