婴儿营养导致的生长如何影响肥胖及日后的疾病风险。
How growth due to infant nutrition influences obesity and later disease risk.
作者信息
Brands Brigitte, Demmelmair Hans, Koletzko Berthold
机构信息
Dr. von Hauner Children's Hospital, University of Munich Medical Centre, Munich, Germany.
出版信息
Acta Paediatr. 2014 Jun;103(6):578-85. doi: 10.1111/apa.12593. Epub 2014 Mar 13.
UNLABELLED
Infant nutrition has a major impact on immediate outcomes and long-term health and later disease risks, such as obesity and related disorders, a phenomenon referred to as 'metabolic programming'. This review discusses the currently postulated hypotheses and mechanisms investigated by the EarlyNutrition project.
CONCLUSION
Rapid weight gain in the first 2 years of life, most notably mediated by diary protein, affects the insulin-like growth factor metabolic pathways. Epigenetic processes seem to play a role.
未标注
婴儿营养对近期结局、长期健康及日后疾病风险（如肥胖及相关病症）有重大影响，这一现象被称为“代谢编程”。本综述讨论了早期营养项目目前所假定的假说及研究的机制。
结论
生命最初2年体重快速增加，最显著的是由乳类蛋白介导，影响胰岛素样生长因子代谢途径。表观遗传过程似乎发挥了作用。
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