中国深圳梅毒母婴传播减少 10 年

Reduction in mother-to-child transmission of syphilis for 10 years in Shenzhen, China.

机构信息

From the *Department of Dermatology and STD, Shenzhen Centre for Chronic Disease Control and Prevention, Shenzhen, China; †Department of Dermatology and ‡Central Laboratory, Shenzhen Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong, China; and §Xi Xiang People's Hospital, Bao'an District, Shenzhen, Guangdong, China.

出版信息

Sex Transm Dis. 2014 Mar;41(3):188-93. doi: 10.1097/OLQ.0000000000000097.

DOI:10.1097/OLQ.0000000000000097

PMID:24521725

Abstract

BACKGROUND

Untreated maternal syphilis can result in the fetuses being infected. Severe adverse pregnancy outcomes include stillbirth, perinatal death, low birth weight, and congenital syphilis (CS). The World Health Organization has already classified global elimination of CS as a priority. However, this preventable disease is still threatening people's health in the world.

METHODS

A Programme of Prevention of Mother-to-Child Transmission of Syphilis in Shenzhen was launched in 2002. All pregnant women in Shenzhen were screened for syphilis by serological methods at their first prenatal care visit. The infected individuals were treated with 3 weekly injections of 2.4 million units of benzathine penicillin. The babies were followed up until 18 months old to diagnose CS.

RESULTS

Up to 2011, the Programme of Prevention of Mother-to-Child Transmission of Syphilis in Shenzhen screened 2,077,362 pregnant women and intervened in 7668 mothers infected with syphilis. The screened rate among pregnant women increased from 89.8% in 2002 to 97.4% in 2011. The proportion of those having adverse pregnant outcomes (including spontaneous abortion, premature delivery, and stillbirth) decreased from 27.3% in 2003 to 8.2% in 2011. The incidence of CS decreased from 115/100,000 in 2002 to 10/100,000 (live births) in 2011.

CONCLUSIONS

In 2002, in the face of rising CS numbers, Shenzhen adapted a syphilis control program that involved cost-free testing for pregnant women, commitment and collaboration at multiple levels of the health system, and strong supervision and government guidance. Local program and surveillance data suggest that the program has been very successful in reducing CS incidence.

摘要

背景

未经治疗的母体梅毒可导致胎儿感染。严重的不良妊娠结局包括死产、围产儿死亡、低出生体重和先天性梅毒（CS）。世界卫生组织已将全球消除 CS 列为优先事项。然而，这种可预防的疾病仍在威胁着全世界人民的健康。

方法

2002 年，深圳启动了预防梅毒母婴传播项目。所有在深圳的孕妇在首次产前检查时均通过血清学方法筛查梅毒。感染个体用每周 3 次、每次 240 万单位的苄星青霉素治疗。对婴儿进行随访至 18 个月以诊断 CS。

结果

截至 2011 年，深圳预防梅毒母婴传播项目共筛查 2077362 名孕妇，干预 7668 名梅毒感染母亲。孕妇筛查率从 2002 年的 89.8%上升到 2011 年的 97.4%。不良妊娠结局（包括自然流产、早产和死产）的比例从 2003 年的 27.3%下降到 2011 年的 8.2%。CS 的发病率从 2002 年的 115/10 万下降到 2011 年的 10/10 万（活产）。