Bhatti Abu Bakar Hafeez, Ahmed Irfan, Ghauri Rashid Khan, Saeed Qamar, Mir Khurram
Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan E-mail :
Asian Pac J Cancer Prev. 2014;15(1):277-80. doi: 10.7314/apjcp.2014.15.1.277.
Testicular cancer management is considered a marvel of modern science with excellent treatment results. Pakistan has a distinct ethnic variation and geographic distribution but data regarding clinical presentation of testicular tumors and their management is under reported. The objective of this study was to determine clinical profile, treatment modalities and survival outcome of testicular tumors in the Pakistani population.
A retrospective review of patients who received treatment for testicular cancer at Shaukat Khanum Cancer Hospital from January 2009 to December 2012 was performed. Patient demographics, clinical features at presentation and treatment modalities were assessed. For categorical variables chi square test was used. Survival was calculated using Kaplan Meier survival curves and Log rank test was employed to determine significance.
The most common tumor was mixed germ cell tumor in 49% patients. For all tumor variants except seminoma, stage III was the most common clinical stage at presentation. Majority of patients with non seminomatous germ cell tumors presented in the15-30 year age group as compared to seminoma which was most prevalent in the 30-40 year age group. Orchiectomy followed by chemotherapy was the most common treatment modality in 80% patients. Expected 5 year survival for seminomas and non- seminomatous germ cell tumors was 96% and 90% respectively which was not significantly different (p=0.2).
Despite a distinct clinical profile of testicular tumors in Pakistani population, survival is comparable with published reports.
睾丸癌的治疗被认为是现代科学的一项奇迹，治疗效果极佳。巴基斯坦存在明显的种族差异和地理分布，但关于睾丸肿瘤临床表现及其治疗的数据报告不足。本研究的目的是确定巴基斯坦人群中睾丸肿瘤的临床特征、治疗方式和生存结果。
对2009年1月至2012年12月在沙卡特汗姆癌症医院接受睾丸癌治疗的患者进行回顾性研究。评估患者的人口统计学特征、就诊时的临床特征和治疗方式。对于分类变量，使用卡方检验。采用Kaplan-Meier生存曲线计算生存率，并使用对数秩检验确定其显著性。
最常见的肿瘤是混合性生殖细胞肿瘤，占49%的患者。除精原细胞瘤外，所有肿瘤变体在就诊时最常见的临床分期是III期。与精原细胞瘤在30-40岁年龄组最为普遍相比，大多数非精原细胞瘤性生殖细胞肿瘤患者出现在15-30岁年龄组。80%的患者最常见的治疗方式是睾丸切除术后化疗。精原细胞瘤和非精原细胞瘤性生殖细胞肿瘤的预期5年生存率分别为96%和90%，差异无统计学意义（p=0.2）。
尽管巴基斯坦人群中睾丸肿瘤有独特的临床特征，但其生存率与已发表的报告相当。
