土耳其膀胱癌患者中Dickkopf-1水平及其与临床病理特征的关联。
Dickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features.
作者信息
Kaba Mehmet, Pirincci Necip, Benli Erdal, Gecit Ilhan, Gunes Mustafa, Yuksel Mehmet Bilgehan, Tok Adem, Kemik Ahu Sarbay
机构信息
Department of Urology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey E-mail :
出版信息
Asian Pac J Cancer Prev. 2014;15(1):381-4. doi: 10.7314/apjcp.2014.15.1.381.
BACKGROUND
Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer.
MATERIALS AND METHODS
DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA).
RESULTS
Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001).
CONCLUSIONS
The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
背景
有证据表明，Dickkopf-1（DKK-1）水平可能是癌症风险的生物标志物。本研究旨在评估膀胱癌患者的DKK-1及其与临床病理特征的相关性。
材料与方法
在90例膀胱癌患者经尿道肿瘤切除术前采集血清样本，测定DKK-1水平。采用酶联免疫吸附测定法（ELISA）测定DKK-1浓度。
结果
术前DKK-1水平升高与肿瘤分期（p<0.001）、分级（p<0.001）和组织学分级（p<0.001）相关。
结论
我们的研究结果表明，血清DKK-1水平与疾病进展和肿瘤分级增加均相关。因此，术前血清DKK-1升高可能是确定膀胱癌以及检测临床预后可能较差患者的一种新标志物。
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