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通过静脉注射髓鞘碱性蛋白,同时给予免疫抑制剂和皮质类固醇,可能实现对多发性硬化症免疫反应的抑制。

Suppression of the immune reaction in multiple sclerosis might be achieved by intravenous injections of myelin basic protein, concomitant with the administration of an immunosuppressant and a corticosteroid.

作者信息

Eidinoff H

机构信息

Department of Pathology New York Medical College, Valhalla 10595.

出版信息

Med Hypotheses. 1988 Apr;25(4):219-22. doi: 10.1016/0306-9877(88)90033-3.

Abstract

The author presents evidence from published papers of research done by numerous investigators that Multiple, Sclerosis (MS) is an autoimmune disease, that the target tissue is the myelin sheath which covers the nerve fibers in the brain and spinal cord, that Myelin Basic Protein (MBP) is the antigen or one of the antigens involved, that the autoimmune reaction is effected by sensitized lymphocytes together with a specific antibody, that Experimental Allergic Encephalomyelitis (EAE) produced in animals can be used as a model for MS, and that the autoimmune reaction in MS can possibly be suppressed by the use of MBP given by an intravenous procedure together with an immunosuppressive drug and a corticosteroid.

摘要

作者列举了众多研究者发表的论文中的证据,表明多发性硬化症(MS)是一种自身免疫性疾病,其靶组织是覆盖大脑和脊髓神经纤维的髓鞘,髓鞘碱性蛋白(MBP)是相关抗原或其中一种抗原,自身免疫反应由致敏淋巴细胞和特异性抗体共同作用引发,动物实验性变应性脑脊髓炎(EAE)可作为MS的模型,并且通过静脉注射MBP联合免疫抑制药物和皮质类固醇,可能抑制MS中的自身免疫反应。

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