Xiong Tianyuan, Yang Jiqiao, Wang Haichuan, Wu Fanyi, Liu Yang, Xu Rui, Lv Zi, Xue Pei, Cao Wen, Zhang Yonggang
West China Hospital/West China Medical School, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
Mol Biol Rep. 2014;41(4):2629-34. doi: 10.1007/s11033-014-3121-x. Epub 2014 Feb 18.
The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case-control studies concerning the association between the XPD Lys751Gln polymorphism and bladder cancer risk were included in the meta-analysis. The results suggested that the Lys751Gln polymorphism was not associated with an increased risk of bladder cancer in the dominant model (OR = 1.03, 95 % CI 0.95-1.11, P = 0.53 for Lys/Gln+Gln/Gln vs. Lys/Lys) in overall analysis. In the subgroup analysis by ethnicity, no significant association was found in Caucasians or Asians. Other comparatives suggested a slight significant association between the polymorphism with the risk of bladder cancer in the recessive comparative (OR = 1.14, 95 % CI 1.02-1.29, P = 0.03). The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. In the future, more large-scale case-control studies are needed to validate our results.
XPD基因中的Lys751Gln多态性已被认为是膀胱癌的一个风险因素，然而结果尚无定论。本研究的目的是通过荟萃分析评估其关联性。共有15项关于XPD Lys751Gln多态性与膀胱癌风险之间关联的病例对照研究纳入了荟萃分析。结果表明，在总体分析中，显性模型（Lys/Gln + Gln/Gln与Lys/Lys相比，OR = 1.03，95%CI 0.95 - 1.11，P = 0.53）中，Lys751Gln多态性与膀胱癌风险增加无关。在按种族进行的亚组分析中，白种人或亚洲人中均未发现显著关联。其他比较表明，在隐性比较中，该多态性与膀胱癌风险之间存在轻微显著关联（OR = 1.14，95%CI 1.02 - 1.29，P = 0.03）。当前的荟萃分析表明，XPD基因中的Lys751Gln多态性可能是膀胱癌的一个风险因素。未来，需要更多大规模的病例对照研究来验证我们的结果。
