XPD基因中Lys751Gln多态性与膀胱癌风险的关联。
The association between the Lys751Gln polymorphism in the XPD gene and the risk of bladder cancer.
作者信息
Xiong Tianyuan, Yang Jiqiao, Wang Haichuan, Wu Fanyi, Liu Yang, Xu Rui, Lv Zi, Xue Pei, Cao Wen, Zhang Yonggang
机构信息
West China Hospital/West China Medical School, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
出版信息
Mol Biol Rep. 2014;41(4):2629-34. doi: 10.1007/s11033-014-3121-x. Epub 2014 Feb 18.
The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case-control studies concerning the association between the XPD Lys751Gln polymorphism and bladder cancer risk were included in the meta-analysis. The results suggested that the Lys751Gln polymorphism was not associated with an increased risk of bladder cancer in the dominant model (OR = 1.03, 95 % CI 0.95-1.11, P = 0.53 for Lys/Gln+Gln/Gln vs. Lys/Lys) in overall analysis. In the subgroup analysis by ethnicity, no significant association was found in Caucasians or Asians. Other comparatives suggested a slight significant association between the polymorphism with the risk of bladder cancer in the recessive comparative (OR = 1.14, 95 % CI 1.02-1.29, P = 0.03). The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. In the future, more large-scale case-control studies are needed to validate our results.
XPD基因中的Lys751Gln多态性已被认为是膀胱癌的一个风险因素，然而结果尚无定论。本研究的目的是通过荟萃分析评估其关联性。共有15项关于XPD Lys751Gln多态性与膀胱癌风险之间关联的病例对照研究纳入了荟萃分析。结果表明，在总体分析中，显性模型（Lys/Gln + Gln/Gln与Lys/Lys相比，OR = 1.03，95%CI 0.95 - 1.11，P = 0.53）中，Lys751Gln多态性与膀胱癌风险增加无关。在按种族进行的亚组分析中，白种人或亚洲人中均未发现显著关联。其他比较表明，在隐性比较中，该多态性与膀胱癌风险之间存在轻微显著关联（OR = 1.14，95%CI 1.02 - 1.29，P = 0.03）。当前的荟萃分析表明，XPD基因中的Lys751Gln多态性可能是膀胱癌的一个风险因素。未来，需要更多大规模的病例对照研究来验证我们的结果。
Zotero 插件