绘制猪瘟病毒溶菌酶水平和免疫球蛋白G阻断百分比的数量性状基因座图谱。
Mapping quantitative trait loci for the lysozyme level and immunoglobulin G blocking percentage of classical swine fever virus.
作者信息
Lu X, Gong Y F, Liu J F, Liu Y, Zhang Q
机构信息
Key Laboratory Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of AgroBiotechnology, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Key Laboratory Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of AgroBiotechnology, College of Animal Science and Technology, China Agricultural University, Beijing, China
出版信息
Genet Mol Res. 2014 Jan 17;13(1):283-90. doi: 10.4238/2014.January.17.13.
Increased disease resistance through improved general immune capacity would be beneficial for the welfare and productivity of farm animals. Classical swine fever (CSF) is a contagious disease in farm animals. The immunoglobulin G (IgG) blocking percentage of CSF virus (CSFV) in serum is an essential diagnostic parameter in veterinary practice. In addition, lysozymes are a part of the innate immune system. To identify quantitative trait loci (QTL) for IgG blocking percentage of CSFV and lysozyme concentration, IgG blocking percentage and lysozyme concentration in serum were measured in a composite pig population before and after challenge with modified live CSF vaccine. Through genome-wide mapping by MQREML analysis and the SOLAR software, several QTL for the lysozyme concentration and the IgG blocking percentage of CSFV were identified, respectively. Within these QTL regions, some known genes were revealed, and some of them may serve as candidate genes in the pig.
通过提高整体免疫能力增强抗病性，对家畜的健康和生产力有益。经典猪瘟（CSF）是家畜中的一种传染病。血清中猪瘟病毒（CSFV）的免疫球蛋白G（IgG）阻断百分比是兽医实践中的一项重要诊断参数。此外，溶菌酶是先天免疫系统的一部分。为了鉴定CSFV的IgG阻断百分比和溶菌酶浓度的数量性状位点（QTL），在使用改良活CSF疫苗攻毒前后，对一个复合猪群体的血清中IgG阻断百分比和溶菌酶浓度进行了测量。通过MQREML分析和SOLAR软件进行全基因组定位，分别鉴定了几个与溶菌酶浓度和CSFV的IgG阻断百分比相关的QTL。在这些QTL区域内，发现了一些已知基因，其中一些可能作为猪的候选基因。
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