Ogihara T, Ikeda M, Goto Y, Yoshinaga K, Kumahara Y, Iimura O, Ishii M, Murakami E, Takeda T, Kokubu T
Department of Medicine and Geriatrics, Osaka University Medical School, Japan.
J Cardiovasc Pharmacol. 1987;10 Suppl 11:S108-12.
The effect of once daily low-dose carvedilol on circadian variations of blood pressure (BP) was studied in Japanese patients with mild or moderate essential hypertension. Thirty-one patients were admitted to hospital whose BP was 150/90 mm Hg/day or greater and they participated in the study. After a placebo period of 1 week, 5 or 10 mg carvedilol was given once daily in the morning for 3 to 7 days, and if BP reduction was not sufficient, the dose was increased to 20 mg daily. The blood pressure variation was monitored before and 1, 2, 4, 6, 8, 10, 12, and 24 h after administration of the drug on the last day of placebo and final dose of carvedilol. Of the 31 cases receiving carvedilol once daily, cumulative effectiveness (13 mm Hg reduction in mean BP) was 48.4% at 10 mg/day and 54.8% at 20 mg/day. Both systolic and diastolic pressures decreased significantly and heart rate decreased slightly. There was no significant difference between the standard deviations of BP on the last days of the control period and the carvedilol treatment. The difference between maximum and minimum BP during the day was not significant between the two periods. Circadian variations of heart rate were also not significantly different for the two periods. This indicates that carvedilol did not have any effect on circadian variations of BP and heart rate. The present study also suggests that low-dose carvedilol once daily may be effective in the treatment of hypertension.
在日本轻度或中度原发性高血压患者中，研究了每日一次低剂量卡维地洛对血压（BP）昼夜变化的影响。31例收缩压≥150/90 mmHg的患者入院并参与本研究。经过1周的安慰剂期后，每天早晨给予5或10 mg卡维地洛，持续3至7天，如果血压降低不充分，则将剂量增加至每日20 mg。在安慰剂期最后一天和卡维地洛最后一剂给药前及给药后1、2、4、6、8、10、12和24小时监测血压变化。在31例每日服用一次卡维地洛的患者中，每日10 mg时累积有效率（平均血压降低13 mmHg）为48.4%，每日20 mg时为54.8%。收缩压和舒张压均显著降低，心率略有下降。对照期最后一天和卡维地洛治疗期最后一天的血压标准差之间无显著差异。两个时期白天最高血压与最低血压之间的差异不显著。两个时期心率的昼夜变化也无显著差异。这表明卡维地洛对血压和心率的昼夜变化没有任何影响。本研究还表明，每日一次低剂量卡维地洛可能对高血压治疗有效。
