Li Yi, Xu Ming-Hua
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
Chem Commun (Camb). 2014 Apr 14;50(29):3771-82. doi: 10.1039/c3cc49431d.
Since 2003, the discovery of chiral dienes as steering ligands in asymmetric processes has opened the field of chiral chelating olefin catalysis. However, despite the impressive advances, the development of readily accessible and catalytically promising chiral olefins has been much less successful. In very recent years, chiral sulfur-containing olefins have emerged as a new exciting class of hybrid ligands for asymmetric catalysis. This article summarizes our efforts in developing extremely simple chiral sulfur-olefins as ligands for a variety of transition-metal-catalyzed asymmetric transformations, and the recent progress by other groups in the design and use of sulfinamide- or sulfoxide-based olefins in asymmetric catalysis.
自2003年以来，手性二烯作为不对称过程中的导向配体被发现，开启了手性螯合烯烃催化领域。然而，尽管取得了令人瞩目的进展，但易于获得且具有催化潜力的手性烯烃的开发却不太成功。近年来，手性含硫烯烃已成为一类令人兴奋的新型不对称催化混合配体。本文总结了我们在开发极其简单的手性硫烯烃作为用于各种过渡金属催化的不对称转化的配体方面所做的努力，以及其他研究小组最近在设计和使用基于亚磺酰胺或亚砜的烯烃进行不对称催化方面取得的进展。
