Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Pharos University, Egypt.
Oral Biology Department, King Abdulaziz University, Jeddah, Saudi Arabia ; Oral Biology Department, Faculty of Dentistry, Alexandria University, Egypt.
J Tissue Eng. 2014 Feb 2;5:2041731414521707. doi: 10.1177/2041731414521707. eCollection 2014.
The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin-pulp complex to the enamel matrix derivative (Emdogain(®) gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs' teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino-pulpal complex regeneration.
年轻恒牙活髓切断术的成功与否取决于盖髓材料的正确选择。本研究旨在评估牙本质-牙髓复合体对釉基质衍生物（Emdogain(®)凝胶）的组织学和组织形态计量学反应，与作为未成熟年轻恒牙髓腔覆盖剂的氢氧化钙进行比较。在 1 个月时，两组均可见到在损伤和健康牙髓组织之间的交界处完全桥接冠髓的牙本质样组织。随着时间的推移，牙本质桥在氢氧化钙组中厚度增加，但在 Emdogain 处理组中崩解并完全消失。仅在 Emdogain 处理组中可见进行性炎症和总牙髓变性。Emdogain 处理过的牙齿的根尖通过附着在新牙槽骨上的牙骨质而成熟并闭合，牙周韧带排列良好。在年轻恒牙中，Emdogain 可能是牙周组织的良好候选物，但不是牙本质牙髓复合体的再生。
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