尼卡地平对自发性高血压大鼠血压及血小板胞浆游离钙浓度的影响。
Effects of nicardipine on blood pressure and platelet cytosolic free calcium concentration in SHR.
作者信息
Baba A, Fukuda K, Kuchii M, Hano T, Nishio I, Masuyama Y
机构信息
Department of Medicine, Wakayama Medical College, Japan.
出版信息
J Cardiovasc Pharmacol. 1987;10 Suppl 10:S70-1.
Intracellular free calcium concentration was measured by the fluorescent calcium indicator quin2 method in platelets of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats, and the effects of nicardipine on platelet cytosolic free calcium concentration were investigated. Cytosolic free calcium concentration was significantly increased in platelets of 4-, 11-, and 14-week-old SHR compared with age-matched WKY rats. Platelet cytosolic free calcium concentration in 14-week-old male SHR was significantly decreased 1 h after the administration of nicardipine (5 mg/kg p.o.), while that in WKY rats remained unchanged. These results suggest that transmembrane Ca2+ influx is genetically increased in SHR.
采用荧光钙指示剂喹啉-2法测定自发性高血压大鼠（SHR）和Wistar-Kyoto（WKY）大鼠血小板内的游离钙浓度，并研究尼卡地平对血小板胞质游离钙浓度的影响。与年龄匹配的WKY大鼠相比，4周龄、11周龄和14周龄SHR的血小板胞质游离钙浓度显著升高。给予尼卡地平（5mg/kg口服）1小时后，14周龄雄性SHR的血小板胞质游离钙浓度显著降低，而WKY大鼠的则保持不变。这些结果表明，SHR中跨膜Ca2+内流在遗传上增加。
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