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球囊骶骨成形术作为转移性骨破坏和病理性骨折患者的姑息性疼痛治疗方法。

Balloon sacroplasty as a palliative pain treatment in patients with metastasis-induced bone destruction and pathological fractures.

作者信息

Andresen R, Radmer S, Lüdtke C W, Kamusella P, Wissgott C, Schober H C

机构信息

Institute of Diagnostic and Interventional Radiology/Neuroradiology, Westkuestenklinikum Heide, Academic Teaching Hospital of the Universities of Kiel, Luebeck and Hamburg, Heide.

Orthopedic Surgery and Traumatology, Center of Orthopedics, Berlin.

出版信息

Rofo. 2014 Sep;186(9):881-6. doi: 10.1055/s-0033-1356418. Epub 2014 Feb 20.

Abstract

PURPOSE

In the case of metastatic involvement of the sacrum with destruction and consecutive pathological fracture, intense disabling pain is one of the defining factors. The feasibility, safety and pain development with cement augmentation were to be investigated.

MATERIALS AND METHODS

CT-guided balloon sacroplasty was conducted in 10 patients with metastasis-induced bone destruction of the sacrum. After establishment of the entry point, a K-wire was first introduced as far as the central tumor lesion via the short, or transiliac axis. A cannula was then positioned over the wire. Under CT guidance, a balloon catheter was introduced through the cannula and inflated and deflated several times. The PMMA cement was then injected into the preformed cavity. The procedure was completed by a spiral CT control using the thin-slice technique. Pain intensity was determined using a visual analog scale (VAS) before the procedure, on the 2nd postoperative day and 6 months after the intervention. Finally, the patients were asked to state how satisfied they were.

RESULTS

Balloon sacroplasty was technically feasible in all patients. The control CT scan showed central distribution of the cement in the tumor lesion. On average 6 +/- 1.78 (4 - 10) ml of PMMA cement were introduced per treated lesion. A significant (p < 0.001) reduction in pain according to the VAS occurred in all patients from 9.3 +/- 0.67 (8 - 10) pre-operatively to 2.7 +/- 1.28 (1 - 5) on the 2nd postoperative day and 2.9 +/- 0.81 (2 - 5) 6 months after the intervention. All of the patients were re-mobilized after the procedure and underwent the further therapeutic measures as planned.

CONCLUSION

Balloon sacroplasty is a helpful therapeutic option in the overall palliative treatment of patients with tumor-induced destruction. It is a safe and practicable procedure that markedly reduces disabling pain.

摘要

目的

在骶骨发生转移瘤累及并伴有骨质破坏及连续性病理性骨折的情况下,剧烈的致残性疼痛是一个决定性因素。本研究旨在探讨骨水泥强化治疗的可行性、安全性及疼痛改善情况。

材料与方法

对10例因转移瘤导致骶骨骨质破坏的患者实施CT引导下球囊骶骨成形术。确定进针点后,首先经短轴或经髂骨轴将一根克氏针插入至中央肿瘤病灶处。然后将套管置于针上。在CT引导下,通过套管插入球囊导管并多次充气和放气。随后将聚甲基丙烯酸甲酯(PMMA)骨水泥注入预先形成的腔隙。采用薄层技术通过螺旋CT进行对照以完成该操作。在术前、术后第2天及干预后6个月使用视觉模拟量表(VAS)确定疼痛强度。最后,询问患者的满意度。

结果

球囊骶骨成形术在所有患者中技术上均可行。对照CT扫描显示骨水泥在肿瘤病灶内呈中央分布。每个治疗病灶平均注入6±1.78(4 - 10)ml的PMMA骨水泥。所有患者的VAS疼痛评分均显著降低(p < 0.001),从术前的9.3±0.67(8 - 10)降至术后第2天的2.7±1.28(1 - 5)以及干预后6个月的2.9±0.81(2 - 5)。所有患者术后均恢复活动,并按计划接受进一步治疗措施。

结论

球囊骶骨成形术是肿瘤所致破坏患者整体姑息治疗中的一种有益治疗选择。它是一种安全可行的手术,能显著减轻致残性疼痛。

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