IEEE Trans Biomed Eng. 2014 Mar;61(3):911-9. doi: 10.1109/TBME.2013.2292559.
One of the challenges in MRI-controlled hyperthermia cancer treatment for localized tumor is that the tissue properties are dynamic and difficult to measure. Therefore, tuning the optimal gains for a constant gain controller can be challenging. In this paper, a new multi-input single-output adaptive controller strategy is proposed to address these problems. The inputs to the controller block are the frequency, rotation rate, and applied power level of an interstitial applicator, and the output is the boundary temperature during treatment. The time-varying gains of the new controller are updated over time using Lyapunov-based stability analysis. The robustness of the new controller to changes in the parameters of the tissue is investigated and compared to a constant gain controller through simulation studies. Simulations take into account changes in tissue properties and other conditions that may be encountered in a practical clinical situation. Finally, the effectiveness of the proposed controller is validated through an experimental study.
在 MRI 控制的局部肿瘤热疗癌症治疗中，一个挑战是组织特性是动态的且难以测量。因此，为恒增益控制器调整最佳增益可能具有挑战性。在本文中，提出了一种新的多输入单输出自适应控制器策略来解决这些问题。控制器块的输入是间质施源器的频率、旋转速度和施加的功率水平，输出是治疗过程中的边界温度。新控制器的时变增益使用基于 Lyapunov 的稳定性分析进行随时间更新。通过仿真研究，研究了新控制器对组织参数变化的鲁棒性，并与恒增益控制器进行了比较。仿真考虑了组织特性的变化和实际临床情况下可能遇到的其他情况。最后，通过实验研究验证了所提出的控制器的有效性。
