[东北红豆杉针叶中的非紫杉烷类化学成分]

[Non-taxoid chemical constituents from needles of Taxus cuspidata].

作者信息

Su Jian, Zhang Man-Li, Huo Chang-Hong, Shi Qing-Wen, Wu Yi-Bing

机构信息

Hebei Provincial Food and Drug Inspection Institute, Shijiazhuang 050011, China.

Department of Medicinal Natural Product Chemistry, Hebei Medical University, Shijiazhuang 050017, China.

出版信息

Zhong Yao Cai. 2013 Aug;36(8):1267-70.

PMID:24558823

Abstract

OBJECTIVE

To study the chemical constituents in the needles of Taxus cuspidata collected from Japan.

METHODS

Chemical constituents were isolated by column chromatography, TLC and preparative HPLC. The structures were identified on the basis of NMR spectral analysis.

RESULTS

Six non-taxoids were isolated and identified as: 4-[(1E)-3-hydroxy-1-buten-1-yl]-3,5,5-trimethyl-2-cyclohexen-1-one (1), megastigm-5-ene-3, 9-diol (2), 6alpha-epoxy-7-megastigmen-9-one (3), 4-(4-hydroxyphenyl)-2-butanone (4), 12-hydroxy-alpha-cyperone (5), scutellarein-7-O-alpha-L-rhamnoside (6).

CONCLUSION

Compounds 2 - 6 are isolated from Taxus genus for the first time. Compound 1 is obtained from Taxus cuspidata for the first time.

摘要

目的

研究从日本采集的东北红豆杉针叶中的化学成分。

方法

通过柱色谱、薄层色谱和制备型高效液相色谱分离化学成分。基于核磁共振光谱分析鉴定结构。

结果

分离并鉴定出6种非紫杉烷类化合物，分别为：4-[(1E)-3-羟基-1-丁烯-1-基]-3,5,5-三甲基-2-环己烯-1-酮（1）、大柱香波龙-5-烯-3,9-二醇（2）、6α-环氧-7-大柱香波龙-9-酮（3）、4-(4-羟基苯基)-2-丁酮（4）、12-羟基-α-香附酮（5）、黄芩苷元-7-O-α-L-鼠李糖苷（6）。