IP3 受体通道聚集在卵母细胞成熟过程中 Ca2+波传播中的作用。
The role of IP3 receptor channel clustering in Ca2+ wave propagation during oocyte maturation.
机构信息
Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio, USA.
Department of Physics, University of South Florida, Tampa, Florida, USA.
出版信息
Prog Mol Biol Transl Sci. 2014;123:83-101. doi: 10.1016/B978-0-12-397897-4.00006-1.
During oocyte maturation, the calcium-signaling machinery undergoes a dramatic remodeling resulting in distinctly different calcium-release patterns on all organizational scales from puffs to waves. The dynamics of the Ca(2+) release wave in mature as compared to immature oocytes are defined by a slower propagation speed and longer duration of the high Ca(2+) plateau. In this chapter, we use computational modeling to identify the changes in the signaling machinery, which contribute most significantly to the alterations observed in Ca(2+) wave propagation during Xenopus oocyte maturation. In addition to loss of store-operated calcium entry and internalization of plasma membrane pumps, we propose that spatial reorganization of the IP3 receptors in the plane of the ER membrane is a key factor for the observed signaling changes in Ca(2+) wave propagation.
在卵母细胞成熟过程中，钙信号机制发生剧烈重构，导致从脉冲到波的所有组织尺度上的钙释放模式明显不同。与不成熟卵母细胞相比，成熟卵母细胞中钙释放波的动力学特征表现为钙峰的传播速度较慢和持续时间较长。在本章中，我们使用计算建模来鉴定信号机制的变化，这些变化对爪蟾卵母细胞成熟过程中观察到的钙波传播变化有重要贡献。除了储存操作钙内流的丧失和质膜泵的内化之外，我们还提出 IP3 受体在 ER 膜平面上的空间重排是观察到的钙波传播中信号变化的关键因素。
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