Nam Kyoung Won, Lee Sang Bong, Kim In Young, Kim Kwang Gi, Park Sang Jae
Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea.
World J Gastroenterol. 2014 Feb 7;20(5):1325-31. doi: 10.3748/wjg.v20.i5.1325.
To develop a new hemostatic device for endoscopic surgery that can control the bleeding without completely occluding the bleeding vessel.
A hemostatic clip and its applier that can stanch bleeding while maintaining blood flow through the clipped vessel was introduced, and the performance of the proposed clip was evaluated using in vitro and in vivo experiments.
During in vitro experiments, no leakage was found after clipping at cuts made in artificial vessels, and flow was maintained through the clipped artificial vessels. In experiments on rats, all the implanted clips occluded the target vessels successfully, and no bleeding or tissue damage was observed at the operative site after the rats were euthanized on postoperative day 7. In experiments on pigs, bleeding stopped immediately after partial clipping of a damaged vessel, and some amount of blood flow was consistently maintained through the clipped vessel after hemostasis.
We believe that the proposed hemostatic clip and clip applier can enhance patient safety during laparoscopic surgery.
开发一种用于内镜手术的新型止血装置,该装置能够在不完全阻塞出血血管的情况下控制出血。
引入一种止血夹及其施夹器,其可在保持血液流经被夹闭血管的同时止血,并通过体外和体内实验评估所提出的夹子的性能。
在体外实验中,在人造血管上进行切割后夹闭时未发现渗漏,并且血液流经被夹闭的人造血管得以维持。在大鼠实验中,所有植入的夹子均成功阻塞了目标血管,并且在术后第7天对大鼠实施安乐死后,在手术部位未观察到出血或组织损伤。在猪实验中,受损血管部分夹闭后出血立即停止,并且止血后通过被夹闭血管持续维持了一定量的血流。
我们认为所提出的止血夹和施夹器可提高腹腔镜手术期间的患者安全性。