Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil; Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston, Houston, TX, USA.
Life Sci. 2014 Apr 17;101(1-2):10-4. doi: 10.1016/j.lfs.2014.02.014. Epub 2014 Feb 25.
The aim of this study was to characterize the mTOR signaling cascade in depression and the actions that antidepressant drugs have on this pathway. Herein, a literature review was performed by verification and comparison of textbooks and journal articles that describe the characterization of the mTOR signaling cascade and its relationship to depression and antidepressant drugs, especially ketamine. Postmortem studies have shown robust deficits in the mammalian target of rapamycin (mTOR) signaling in the prefrontal cortex of subjects diagnosed with major depressive disorder. However, besides the mTOR signaling pathway having an antidepressant response to various drugs, this seems to be more associated with antidepressant N-methyl-d-aspartate (NMDA) receptor antagonists, such as ketamine. The characterization of the mTOR signaling pathway in depression and its action in response to antidepressants show great potential for the identification of new therapeutic targets for the development of antidepressant drugs.
本研究旨在描述抑郁症中 mTOR 信号级联及其抗抑郁药物对该通路的作用。为此，通过验证和比较描述 mTOR 信号级联及其与抑郁症和抗抑郁药物（尤其是氯胺酮）关系的教科书和期刊文章，进行了文献综述。 尸检研究表明，患有重度抑郁症的受试者的前额叶皮质中哺乳动物雷帕霉素靶蛋白 (mTOR) 信号明显不足。 然而，除了 mTOR 信号通路对各种药物具有抗抑郁反应之外，这似乎与抗抑郁 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂（如氯胺酮）的关系更为密切。 抑郁症中 mTOR 信号通路的特征及其对抗抑郁药的作用为开发抗抑郁药物确定新的治疗靶点提供了巨大潜力。
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