在评估多裂肌损伤和萎缩方面，磁共振成像信号强度比测量相对于组织学检查的准确性。
Accuracy of magnetic resonance imaging signal intensity ratio measurements in the evaluation of multifidus muscle injury and atrophy relative to that of histological examinations.
作者信息
Zhi-Jun Hu, Wen-Bin Xu, Shuai Chen, Zhi-Jie Zhou, Feng-Dong Zhao, Xiao-Jing Yu, Ji-Ying Wang, Li-Li Han, Feng Jiang, Guo-Xiang Fu, Dan-Ju Wu, Shun-Wu Fan, Xiang-Qian Fang
机构信息
*Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China †Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China ‡Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China; and §Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China.
出版信息
Spine (Phila Pa 1976). 2014 May 1;39(10):E623-9. doi: 10.1097/BRS.0000000000000286.
STUDY DESIGN
A matched-pairs animal study.
OBJECTIVE
To confirm the accuracy of magnetic resonance imaging (MRI) as a means of evaluating edema and fat degeneration of the multifidus muscle by comparing measurements made using MRI with those made using histological examination.
SUMMARY OF BACKGROUND DATA
MRI is considered a reliable means of evaluating multifidus muscle edema and fat degeneration. However, it is not clear whether its results are always consistent with histological findings.
METHODS
Models of different degrees of multifidus injury were created at the L2-L3, L3-L4, and L4-L5 disc levels in 56 New Zealand white rabbits. These were divided into 4 groups and subjected to different processes: sham surgery, dissection and stripping of the multifidus, crushing of the muscle lasting 1 hour, and crushing of the muscle lasting 2 hours. Two rabbits per group were examined at each of the indicated points in time. Multifidus edema was assessed using fat-suppressed T2 signal intensity ratio of gross multifidus to psoas (T2R) on MRI bilaterally, wet weight and wet:dry weight ratio on the left side (edema-left), and visual edema score on the right side (edema-right). Muscle fat degeneration was detected bilaterally using the T1 signal intensity ratio of gross multifidus to psoas with MRI (T1R) and visual fat degeneration score (fat score) with histology.
RESULTS
Pearson correlation coefficient analyses showed significant correlations (P < 0.001) between left T2R and edema-left (r = 0.927), right T2R and edema-right (r = 0.868), and T1R and fat score (r = 0.804). A paired t test demonstrated no significant differences between MRI measurements and histological changes (P = 0.999, 1.000, and 0.998). Bland-Altman plots also depicted good agreement between MRI measurements and histological changes (limits of agreement: left multifidus edema, ± 0.75; right multifidus edema, ± 1.01; fat degeneration, ± 1.23).
CONCLUSION
The MRI technique is an accuracy means of evaluating multifidus muscle injury and atrophy.
研究设计
配对动物研究。
目的
通过比较磁共振成像（MRI）测量结果与组织学检查测量结果，确认MRI作为评估多裂肌水肿和脂肪变性方法的准确性。
背景数据总结
MRI被认为是评估多裂肌水肿和脂肪变性的可靠方法。然而，其结果是否始终与组织学发现一致尚不清楚。
方法
在56只新西兰白兔的L2-L3、L3-L4和L4-L5椎间盘水平创建不同程度的多裂肌损伤模型。将这些模型分为4组并进行不同处理：假手术、多裂肌的解剖和剥离、持续1小时的肌肉挤压以及持续2小时的肌肉挤压。每组在每个指定时间点检查2只兔子。使用MRI双侧测量多裂肌与腰大肌的脂肪抑制T2信号强度比（T2R）、左侧的湿重和湿重与干重比（水肿-左侧）以及右侧的视觉水肿评分（水肿-右侧）评估多裂肌水肿。使用MRI双侧测量多裂肌与腰大肌的T1信号强度比（T1R）以及组织学的视觉脂肪变性评分（脂肪评分）检测肌肉脂肪变性。
结果
Pearson相关系数分析显示，左侧T2R与水肿-左侧（r = 0.927）、右侧T2R与水肿-右侧（r = 0.868）以及T1R与脂肪评分（r = 0.804）之间存在显著相关性（P < 0.001）。配对t检验显示MRI测量结果与组织学变化之间无显著差异（P = 0.999、1.000和0.998）。Bland-Altman图也显示MRI测量结果与组织学变化之间具有良好的一致性（一致性界限：左侧多裂肌水肿，± 0.75；右侧多裂肌水肿，± 1.01；脂肪变性，± 1.23）。
结论
MRI技术是评估多裂肌损伤和萎缩的准确方法。
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