Adlerberth A, Persson S, Hansson G, Hasselgren P O
Department of Surgery, Ostra Sjukhuset, University of Göteborg, Sweden.
J Clin Endocrinol Metab. 1988 Oct;67(4):663-8. doi: 10.1210/jcem-67-4-663.
The rate of protein synthesis was measured in thyroid tissue obtained from three groups of patients undergoing thyroid surgery: group I (n = 18), hyperthyroid patients preoperatively treated with an antithyroid drug and T4; group II (n = 11), hyperthyroid patients preoperatively treated with a beta-adrenergic antagonist drug; and group III (n = 9), euthyroid patients operated on for multinodular goiter or adenoma. Quantitative morphology was studied in the resected thyroid tissue from the patients in groups I (n = 15) and II (n = 6) who had Graves' disease. While serum thyroid hormone levels became normal during preoperative treatment in group I, they remained elevated in the group II patients. The rate of protein synthesis was 2-fold higher in thyroid tissue from patients in group II than in those in groups I and III. A tendency toward an increased amount of epithelium and a reduced amount of colloid was found in thyroid tissue from patients in group II. There was a positive correlation between the rate of protein synthesis, and distribution of epithelium, and the epithelium to colloid ratio, respectively, in thyroid tissue. These results suggest that the thyroid gland of hyperthyroid patients remains hyperactive during treatment with beta-adrenergic antagonist drugs.
第一组（n = 18），术前用抗甲状腺药物和T4治疗的甲亢患者；第二组（n = 11），术前用β-肾上腺素能拮抗剂药物治疗的甲亢患者；第三组（n = 9），因多结节性甲状腺肿或腺瘤接受手术的甲状腺功能正常患者。对第一组（n = 15）和第二组（n = 6）患有格雷夫斯病患者切除的甲状腺组织进行了定量形态学研究。虽然第一组患者术前治疗期间血清甲状腺激素水平恢复正常，但第二组患者的血清甲状腺激素水平仍保持升高。第二组患者甲状腺组织中的蛋白质合成速率比第一组和第三组患者高出两倍。在第二组患者的甲状腺组织中发现上皮细胞数量有增加趋势，而胶体数量减少。甲状腺组织中蛋白质合成速率、上皮细胞分布以及上皮细胞与胶体比例之间分别存在正相关。这些结果表明，甲亢患者的甲状腺在用β-肾上腺素能拮抗剂药物治疗期间仍保持活跃。
