一个 proneural 基因控制秀丽隐杆线虫神经母细胞的不对称分裂和迁移。
A proneural gene controls C. elegans neuroblast asymmetric division and migration.
机构信息
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China.
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing, China.
出版信息
FEBS Lett. 2014 Apr 2;588(7):1136-43. doi: 10.1016/j.febslet.2014.02.036. Epub 2014 Feb 28.
Proneural genes control the generation of neuroblasts from the neuroepithelium, but their functions in neuroblast asymmetric division and migration remain elusive. Here, we identified Caenorhabditiselegans mutants of a proneural transcription factor (TF) lin-32, in which Q neuroblasts are produced. We showed that LIN-32 functions in parallel with a storkhead TF, HAM-1, to regulate Q neuroblast asymmetric division, and that Q neuroblast migration is inhibited in lin-32 alleles. Consistently, lin-32 is expressed throughout Q neuroblast lineage, suggesting that LIN-32 may promote different target gene expression. Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development.
神经前体细胞基因控制神经上皮细胞向神经母细胞的生成，但它们在神经母细胞不对称分裂和迁移中的功能仍不清楚。在这里，我们鉴定出秀丽隐杆线虫中一个神经前体细胞转录因子（TF）lin-32 的突变体，其中 Q 神经母细胞被产生。我们表明，LIN-32 与一个鹳嘴形 TF，HAM-1，平行发挥作用，以调节 Q 神经母细胞的不对称分裂，并且 lin-32 等位基因中 Q 神经母细胞的迁移被抑制。一致地，lin-32 在整个 Q 神经母细胞谱系中表达，表明 LIN-32 可能促进不同的靶基因表达。因此，我们的研究揭示了一个神经前体细胞基因在神经母细胞发育中的以前未知的功能。
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