Probst Catharina Claudia, Winter Lina Marie, Möller Bettina, Weber Heinz, Weintraub Daniel, Witt Karsten, Deuschl Günther, Katzenschlager Regina, van Eimeren Thilo
Department of Neurology, Kiel University, Kiel, Germany,
J Neurol. 2014 May;261(5):936-42. doi: 10.1007/s00415-014-7299-6. Epub 2014 Mar 9.
Impulsive-compulsive disorders are frequent in patients with Parkinson's disease (PD). Recently, a screening questionnaire and rating scale were developed for these disorders: the questionnaire for impulsive-compulsive disorders (QUIP) and QUIP-rating scale (QUIP-RS). We assessed the validity of these instruments in the German language in order to reevaluate the benefit and to obtain German screening tools in clinical practice. A convenience sample of 156 patients was assessed in Kiel and Vienna. The patients filled out the QUIP-current, the QUIP-anytime and the QUIP-RS. We validated the questionnaires against a gold standard diagnosis via receiver operating characteristic curves and determined optimal cut-off scores for the instruments. Excluding walkabout, which was not shown to be valid, sensitivities ranged from 60-92 % for the QUIP-current, 68-91 % for the QUIP-anytime, and 73-100 % for the QUIP-RS. Specificities were >71 % for QUIP-current, >69 % for QUIP-anytime and >62 % for QUIP-RS. With its very good sensitivities, the QUIP-RS is a valid instrument to assess impulsive-compulsive disorders and makes an early detection of behavioral disorders in PD possible. The QUIP-anytime was also shown to be a valid screening instrument. Both are expected to prove useful in scientific and clinical practice.
冲动控制障碍在帕金森病（PD）患者中很常见。最近，针对这些障碍开发了一种筛查问卷和评定量表：冲动控制障碍问卷（QUIP）和QUIP评定量表（QUIP-RS）。我们评估了这些工具德语版本的有效性，以便重新评估其益处并在临床实践中获得德语筛查工具。在基尔和维也纳对156名患者的便利样本进行了评估。患者填写了QUIP-当前版、QUIP-任意时间版和QUIP-RS。我们通过受试者工作特征曲线对照金标准诊断对问卷进行了验证，并确定了这些工具的最佳截断分数。排除未显示有效的徘徊行为后，QUIP-当前版的敏感性范围为60%-92%，QUIP-任意时间版为68%-91%，QUIP-RS为73%-100%。QUIP-当前版的特异性>71%，QUIP-任意时间版>69%，QUIP-RS>62%。QUIP-RS具有非常好的敏感性，是评估冲动控制障碍的有效工具，能够早期发现PD患者的行为障碍。QUIP-任意时间版也被证明是一种有效的筛查工具。预计这两种工具在科学和临床实践中都将有用。
