卡培他滨与吉西他滨（卡培他滨-吉西他滨、吉西他滨-卡培他滨）用于晚期胰腺癌和胆管癌

Capecitabine and Gemcitabine (CapGem, CG, GemCap) for Advanced Pancreatic and Biliary Tract Cancer.

作者信息

Solimando Dominic A, Waddell J Aubrey

出版信息

Hosp Pharm. 2014 Feb;49(2):127-33. doi: 10.1310/hpj4902-127.

DOI:10.1310/hpj4902-127

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3940678/

Abstract

The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd. #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast.net; or J. Aubrey Waddell, Professor, University of Tennessee College of Pharmacy; Oncology Pharmacist, Pharmacy Department, Blount Memorial Hospital, 907 E. Lamar Alexander Parkway, Maryville, TN 37804, e-mail: waddfour@charter.net.

摘要

癌症化疗的复杂性要求药剂师熟悉所使用的复杂治疗方案和高毒性药物。本专栏回顾了与抗肿瘤治疗的制备、调配和给药相关的各种问题，以及用于治疗恶性疾病的市售和研究性药物。有关主题的问题或建议，请致函小多米尼克·A·索利曼多，肿瘤药学服务公司总裁，地址：弗吉尼亚州阿灵顿市威尔逊大道4201号，邮编110 - 545，电子邮箱：OncRxSvc@comcast.net；或J·奥布里·沃德尔，田纳西大学药学院教授；布朗特纪念医院药学部肿瘤药剂师，地址：田纳西州玛丽维尔市东拉马尔·亚历山大大道907号，邮编37804，电子邮箱：waddfour@charter.net。

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本文引用的文献

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Prospective efficacy and safety study of neoadjuvant gemcitabine with capecitabine combination chemotherapy for borderline-resectable or unresectable locally advanced pancreatic adenocarcinoma.新辅助吉西他滨联合卡培他滨化疗治疗局部进展期或不可切除的边界可切除胰腺癌的前瞻性疗效和安全性研究。

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Comparison of the efficacy and the toxicity between gemcitabine with capecitabine (GC) and gemcitabine with erlotinib (GE) in unresectable pancreatic cancer.吉西他滨联合卡培他滨（GC）与吉西他滨联合厄洛替尼（GE）治疗不可切除胰腺癌的疗效和毒性比较。

J Cancer Res Clin Oncol. 2012 Oct;138(10):1625-30. doi: 10.1007/s00432-012-1234-y. Epub 2012 May 22.

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Optimizing the administration of fixed-dose rate gemcitabine plus capecitabine using an alternating-week schedule: a dose finding and early efficacy study in advanced pancreatic and biliary carcinomas.优化固定剂量率吉西他滨联合卡培他滨的给药方案：一项在晚期胰腺和胆道癌中进行的剂量探索和早期疗效研究。

Am J Clin Oncol. 2012 Oct;35(5):411-7. doi: 10.1097/COC.0b013e3182185888.

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Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer.吉西他滨对比吉西他滨联合卡培他滨治疗晚期胰腺癌的 III 期随机对照研究。

J Clin Oncol. 2009 Nov 20;27(33):5513-8. doi: 10.1200/JCO.2009.24.2446. Epub 2009 Oct 26.

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A phase I trial of Capecitabine+Gemcitabine with radical radiation for locally advanced pancreatic cancer.卡培他滨+吉西他滨联合根治性放疗用于局部晚期胰腺癌的I期试验。

Br J Cancer. 2009 Jan 13;100(1):37-43. doi: 10.1038/sj.bjc.6604827. Epub 2008 Dec 16.

6

Patient-reported outcomes of patients with advanced biliary tract cancers receiving gemcitabine plus capecitabine: a multicenter, phase II trial of the Swiss Group for Clinical Cancer Research.接受吉西他滨联合卡培他滨治疗的晚期胆管癌患者的患者报告结局：瑞士临床癌症研究组的一项多中心II期试验

J Clin Oncol. 2008 Aug 1;26(22):3702-8. doi: 10.1200/JCO.2008.16.5704.

7

Clinical benefit and quality of life in patients with advanced pancreatic cancer receiving gemcitabine plus capecitabine versus gemcitabine alone: a randomized multicenter phase III clinical trial--SAKK 44/00-CECOG/PAN.1.3.001.吉西他滨联合卡培他滨对比单用吉西他滨治疗晚期胰腺癌患者的临床获益及生活质量：一项随机多中心III期临床试验——SAKK 44/00-CECOG/PAN.1.3.001

J Clin Oncol. 2008 Aug 1;26(22):3695-701. doi: 10.1200/JCO.2007.15.6240.

8

A phase II study of capecitabine plus gemcitabine in patients with locally advanced or metastatic pancreatic cancer.卡培他滨联合吉西他滨治疗局部晚期或转移性胰腺癌的II期研究。

Cancer Chemother Pharmacol. 2008 Oct;62(5):763-8. doi: 10.1007/s00280-007-0661-y. Epub 2008 Jan 3.

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Capecitabine plus oxaliplatin (CapOx) versus capecitabine plus gemcitabine (CapGem) versus gemcitabine plus oxaliplatin (mGemOx): final results of a multicenter randomized phase II trial in advanced pancreatic cancer.卡培他滨联合奥沙利铂（CapOx）对比卡培他滨联合吉西他滨（CapGem）对比吉西他滨联合奥沙利铂（mGemOx）：一项晚期胰腺癌多中心随机II期试验的最终结果

Ann Oncol. 2008 Feb;19(2):340-7. doi: 10.1093/annonc/mdm467. Epub 2007 Oct 24.

10

A phase II study of gemcitabine and capecitabine in advanced cholangiocarcinoma and carcinoma of the gallbladder: a single-institution prospective study.吉西他滨与卡培他滨用于晚期胆管癌和胆囊癌的II期研究：一项单机构前瞻性研究。

Ann Surg Oncol. 2007 Nov;14(11):3202-9. doi: 10.1245/s10434-007-9539-9. Epub 2007 Aug 19.

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