spectinamides：一个挑战，一个证明，一个建议。

Spectinamides: a challenge, a proof, and a suggestion.

机构信息

Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal.

Dipartimento di Farmacia, Centro Interdipartimentale BIOPHARMANET_TEC, Università di Parma, Parco Area delle Scienze 27, 43124 Parma, Italy.

出版信息

Trends Microbiol. 2014 Apr;22(4):170-1. doi: 10.1016/j.tim.2014.02.008. Epub 2014 Mar 11.

DOI:10.1016/j.tim.2014.02.008

PMID:24636244

Abstract

New drugs and shorter regimens are needed to fight resistant forms of tuberculosis. Screening of chemical libraries for mining hit compounds is the common approach to find new antituberculars. A new medicinal chemistry and biology directed research rational has recently been successfully described by Lee and coworkers in Nature Medicine.

摘要

需要新的药物和更短的疗程来对抗耐药性结核。从化学文库中筛选出具有潜在疗效的化合物是寻找新的抗结核药物的常用方法。李等人最近在《自然医学》杂志上成功描述了一种新的药物化学和生物学导向的研究策略。