Taguchi K, Asano G
Department of Pathology, Nippon Medical School, Tokyo, Japan.
Acta Pathol Jpn. 1988 May;38(5):615-26. doi: 10.1111/j.1440-1827.1988.tb02334.x.
The relationship between sinusoidal capillarization and pericellular fibrosis was studied in 29 specimens of human liver from patients with alcoholic liver disease. Immunohistochemically, factor VIII-related antigen was not observed in the normal sinusoidal lining cells, but was localized in the capillaries which proliferated in the pericellular fibrotic region. Fibronectin was localized in the proliferated endoplasmic reticulum of newly formed vascular endothelial cells and hepatocytes with the development of pericellular fibrosis, laminin became apparent in the plasmalemmal vesicles of capillary endothelial cells and pericytes and in the endoplasmic reticulum of mesenchymal cells in Disse's space. From these results, it was revealed that pericellular fibrosis was closely related to sinusoidal capillarization. Furthermore, it is suggested that this sinusoidal capillarization may be caused by neovascularization, and that the extracellular matrix produced by endothelial cells, hepatocytes and mesenchymal cells may promote this process.
在29例酒精性肝病患者的人肝标本中研究了肝血窦毛细血管化与细胞周纤维化之间的关系。免疫组织化学显示，正常肝血窦内衬细胞中未观察到因子VIII相关抗原，但其定位于细胞周纤维化区域增殖的毛细血管中。随着细胞周纤维化的发展，纤连蛋白定位于新形成的血管内皮细胞和肝细胞增殖的内质网中，层粘连蛋白在毛细血管内皮细胞和周细胞的质膜小泡以及狄氏间隙中间质细胞的内质网中变得明显。从这些结果可以看出，细胞周纤维化与肝血窦毛细血管化密切相关。此外，提示这种肝血窦毛细血管化可能由新生血管形成引起，并且内皮细胞、肝细胞和间质细胞产生的细胞外基质可能促进这一过程。
