埃塞俄比亚亚的斯亚贝巴流行性水肿的实验室调查。
Laboratory investigation of epidemic dropsy in Addis Ababa, Ethiopia.
作者信息
Assefa Ashenafi, Teka Frehiwot, Guta Mulugeta, Melaku Daniel, Naser Ebrahim, Tesfaye Brehanu, Messele Tsehaynesh, Kebede Amha, Getachew Mesay, Mudi Kissi, Alebachew Achamyeleh, Azazh Aklilu, Bane Abate, Seboxa Teshale, Girma Samson, Muzein Redwan, Urga Kelbessa
出版信息
Ethiop Med J. 2013 Oct;Suppl 2:21-32.
BACKGROUND
Food adulteration including adulteration of edible oils may cause serious health problems. One of the most common edible adulterants is argemone oil. An outbreak of epidemic dropsy occurred in Addis Ababa during May-June, 2008. One hundred and eighty two cases were recorded with twelve confirmed deaths. Dietary history of the cases revealed that vegetable oils were the usual cooking medium.
OBJECTIVE
The aim of the study was hence to investigate the causes of this outbreak.
METHODS
Contaminant identification was done using standard chemical tests, complemented with TLC. Toxicity study was done using Swiss albino mice feed with contaminated and non contaminated standard diet for 30 days.
RESULTS
Laboratory investigation of the edible oils has indicated that 47 of the 280 edible oils analyzed were adulterated with argemone oil. About 81% of the edible oil samples collected from Lideta sub-city were adulterated with argemone oil. Toxicological investigation of the adulterated oils also indicated typical features of argemone alkaloid poisoning in mice.
CONCLUSION
Results of both laboratory analysis and toxicological studies confirmed consumption of edible oils adulterated with argemone oil as the cause of epidemic dropsy in Addis Ababa.
背景
食品掺假，包括食用油掺假，可能会导致严重的健康问题。最常见的食用掺假物之一是刺蒺藜油。2008年5月至6月期间，亚的斯亚贝巴爆发了流行性水肿。记录了182例病例，其中12例确诊死亡。病例的饮食史显示，植物油是常用的烹饪介质。
目的
因此，本研究的目的是调查此次疫情爆发的原因。
方法
使用标准化学测试进行污染物鉴定，并辅以薄层色谱法。使用瑞士白化病小鼠喂食受污染和未受污染的标准饮食30天进行毒性研究。
结果
对食用油的实验室调查表明，在分析的280份食用油样本中，有47份掺有刺蒺藜油。从利代塔市收集的约81%的食用油样本掺有刺蒺藜油。对掺假油的毒理学调查也表明小鼠出现了刺蒺藜生物碱中毒的典型特征。
结论
实验室分析和毒理学研究结果均证实，食用掺有刺蒺藜油的食用油是亚的斯亚贝巴流行性水肿的病因。
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