Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
J Vasc Surg. 2014 Aug;60(2):346-355.e1. doi: 10.1016/j.jvs.2014.02.002. Epub 2014 Mar 21.
Patients presenting with occluded aortobifemoral (ABF) bypass grafts are managed with a variety of techniques. Redo ABF (rABF) bypass procedures are infrequently performed because of concerns about procedural complexity and morbidity. The purpose of this analysis was to compare midterm results of rABF bypass with those of primary ABF (pABF) bypass for aortoiliac occlusive disease to determine if there are significant differences in outcomes.
A retrospective review was performed of all patients undergoing ABF bypass for occlusive disease between January 2002 and March 2012. A total of 19 patients underwent rABF bypass and 194 received pABF bypass during that period. Data for an indication- and comorbidity-matched case-control cohort of 19 elective pABF bypass patients were collected for comparison to the rABF bypass group. Primary end points included rate of major complications as well as 30-day and all-cause mortality. Secondary end points were amputation-free survival and freedom from major adverse limb events.
The rABF bypass patients more frequently underwent prior extra-anatomic or lower extremity bypass operations compared with pABF bypass patients (P = .02); however, no difference was found in the incidence of prior failed endovascular iliac intervention (P = .4). By design, indications for the rABF and pABF bypass groups were the same (claudication, n = 6/6 [31.6%]; P = 1; critical limb ischemia, n = 13/13 [78.4%]; P = 1). Aortic access was more frequently by retroperitoneal exposure in the rABF bypass group (n = 13 vs n = 1; P < .0001), and a significantly higher proportion of the rABF bypass patients required concomitant infrainguinal bypass or intraprocedural adjuncts such as profundaplasty (n = 14 vs n = 5; P = .01). The rABF bypass patients experienced greater blood loss (1097 ± 983 mL vs 580 ± 457 mL; P = .02), received more intraoperative fluids (3400 ± 1422 mL vs 2279 ± 993 mL; P = .01), and had longer overall procedure times (408 ± 102 minutes vs 270 ± 48 minutes; P < .0001). Length of stay (days ± standard deviation) was similar (pABF bypass, 11.2 ± 10.4; rABF bypass, 9.1 ± 4.5; P = .7), and no 30-day or in-hospital deaths occurred in either group. Similar rates of major complications occurred in the two groups (pABF bypass, n = 6 [31.6%]; rABF bypass, n = 4 [21.1%]; observed difference, 9.5%; 95% confidence interval, -17.6% to 36.7%; P = .7). Two-year freedom from major adverse limb events (±standard error mean) was 82% ± 9% vs 78% ± 10% for pABF and rABF bypass patients (log-rank, P = .6). Two-year amputation-free survival was 90 ± 9% vs 89 ± 8% between pABF and rABF bypass patients (P = .5). Two-year survival was 91% ± 9% and 90% ± 9% for pABF and rABF bypass patients (P = .8).
Patients undergoing rABF bypass have higher procedural complexity compared with pABF bypass as evidenced by greater operative time, blood loss, and need for adjunctive procedures. However, similar perioperative morbidity, mortality, and midterm survival occurred in comparison to pABF bypass patients. These results support a role for rABF bypass in selected patients.
患有闭塞性主髂动脉旁路移植术(ABF)的患者可采用多种技术进行治疗。由于担心手术的复杂性和发病率,很少进行再次 ABF(rABF)旁路手术。本分析的目的是比较主髂动脉闭塞性疾病的 rABF 旁路与原发性 ABF(pABF)旁路的中期结果,以确定结果是否存在显著差异。
对 2002 年 1 月至 2012 年 3 月期间因阻塞性疾病行 ABF 旁路手术的所有患者进行回顾性分析。在此期间,19 例患者接受 rABF 旁路手术,194 例患者接受 pABF 旁路手术。为了与 rABF 旁路组进行比较,收集了 19 例择期 pABF 旁路手术患者的适应证和合并症匹配的病例对照队列的数据。主要终点包括主要并发症发生率以及 30 天和全因死亡率。次要终点包括免于截肢和免于主要不良肢体事件。
与 pABF 旁路患者相比,rABF 旁路患者更频繁地接受过先前的非解剖或下肢旁路手术(P =.02);然而,先前失败的腔内髂内干预发生率无差异(P =.4)。根据设计,rABF 和 pABF 旁路组的适应证相同(跛行,n = 6/6 [31.6%];P = 1;严重肢体缺血,n = 13/13 [78.4%];P = 1)。rABF 旁路组更频繁地通过腹膜后暴露进行主动脉入路(n = 13 与 n = 1;P <.0001),并且 rABF 旁路患者中需要同时进行下肢旁路或术中辅助治疗如深部血管成形术的比例显著更高(n = 14 与 n = 5;P =.01)。rABF 旁路患者失血更多(1097 ± 983 mL 与 580 ± 457 mL;P =.02),术中输入更多液体(3400 ± 1422 mL 与 2279 ± 993 mL;P =.01),总手术时间更长(408 ± 102 分钟与 270 ± 48 分钟;P <.0001)。住院时间(天 ± 标准差)相似(pABF 旁路,11.2 ± 10.4;rABF 旁路,9.1 ± 4.5;P =.7),两组均无 30 天或住院内死亡。两组主要并发症发生率相似(pABF 旁路,n = 6 [31.6%];rABF 旁路,n = 4 [21.1%];观察差异,9.5%;95%置信区间,-17.6%至 36.7%;P =.7)。pABF 和 rABF 旁路患者的 2 年主要不良肢体事件无事件率分别为 82% ± 9%和 78% ± 10%(对数秩,P =.6)。2 年无截肢生存率分别为 pABF 和 rABF 旁路患者的 90 ± 9%和 89 ± 8%(P =.5)。2 年生存率分别为 pABF 和 rABF 旁路患者的 91% ± 9%和 90% ± 9%(P =.8)。
与 pABF 旁路相比,rABF 旁路患者的手术复杂性更高,表现为手术时间、失血量和辅助治疗的需求增加。然而,与 pABF 旁路患者相比,围手术期发病率、死亡率和中期生存率相似。这些结果支持在选定的患者中使用 rABF 旁路。