Helical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint.
作者信息
Lee Woohyung, Kwon Sunmi, Kang Philjae, Guzei Ilia A, Choi Soo Hyuk
机构信息
Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
出版信息
Org Biomol Chem. 2014 May 7;12(17):2641-4. doi: 10.1039/c4ob00266k.
PMID:24658224
Abstract
αβα-Tripeptide that contains a cyclic β-amino acid with an eight-membered ring, a cis-2-aminocyclooct-5-enecarboxylic acid (cis-ACOE) or a cis-2-aminocyclooctanecarboxylic acid (cis-ACOC) displayed an 11/9-helical turn in the crystal state. The related α/β-peptide oligomers were shown to adopt 11/9-helical conformations in solution.
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