[(131)i]meta-碘苄胍诱导旁观者效应的剂量计算。
Dose calculations for [(131)i] meta-iodobenzylguanidine-induced bystander effects.
机构信息
Medical Physics and Applied Radiation Sciences Department, McMaster University, Hamilton, Ontario, Canada L8S 4K1;
Targeted Therapy Group, Division of Cancer Science and Molecular Pathology, Glasgow University, Cancer Research United Kingdom Beatson Laboratories, Glasgow, United Kingdom;
出版信息
Dose Response. 2013 May 30;12(1):1-23. doi: 10.2203/dose-response.13-001.Mothersill. eCollection 2014 Jan.
UNLABELLED
Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment.
METHODS
Using the Vynckier - Wambersie dose point kernel, a model for dose rate evaluation was created allowing for calculation of absorbed dose values to two cell lines transfected with the noradrenaline transporter (NAT) gene and treated with [(131)I]MIBG.
RESULTS
The mean doses required to decrease surviving fractions of UVW/NAT and EJ138/NAT cells, which received medium from [(131)I]MIBG-treated cells, to 25 - 30% were 1.6 and 1.7 Gy respectively. The maximum mean dose rates achieved during [(131)I]MIBG treatment were 0.09 - 0.75 Gy/h for UVW/NAT and 0.07 - 0.78 Gy/h for EJ138/NAT. These were significantly lower than the external beam gamma radiation dose rate of 15 Gy/h. In the case of control lines which were incapable of [(131)I]MIBG uptake the mean absorbed doses following radiopharmaceutical were 0.03 - 0.23 Gy for UVW and 0.03 - 0.32 Gy for EJ138.
CONCLUSION
[(131)I]MIBG treatment for ICCM production elicited a bystander dose-response profile similar to that generated by external beam gamma irradiation but with significantly greater cell death.
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针对放射疗法是一种有潜力的治疗一些癌症的方法，并且可能通过旁观者效应得到增强。然而，如果没有吸收剂量的估计，就很难将其效果与传统的外部放射治疗进行比较。
方法
使用 Vynckier-Wambersie 剂量点核，创建了一个剂量率评估模型，允许计算转染去甲肾上腺素转运体（NAT）基因的两种细胞系接受 [(131)I]MIBG 治疗后的吸收剂量值。
结果
使接受 [(131)I]MIBG 处理过的细胞培养基的 UVW/NAT 和 EJ138/NAT 细胞存活分数降低到 25-30%所需的平均剂量分别为 1.6 和 1.7 Gy。在 [(131)I]MIBG 治疗过程中达到的最大平均剂量率分别为 0.09-0.75 Gy/h 用于 UVW/NAT 和 0.07-0.78 Gy/h 用于 EJ138/NAT。这些显著低于外部束伽马辐射剂量率 15 Gy/h。在不能摄取 [(131)I]MIBG 的对照系中，放射性药物后吸收的平均剂量分别为 0.03-0.23 Gy 用于 UVW 和 0.03-0.32 Gy 用于 EJ138。
结论
[(131)I]MIBG 治疗 ICCM 产生的旁观者剂量反应与外部束伽马照射产生的相似，但细胞死亡明显更多。
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