LOX-1 基因多态性与中国北方汉族人群脑梗死的相关性研究。
Association of LOX-1 gene polymorphisms with cerebral infarction in northern Chinese Han population.
机构信息
Department of Neurology, First Affiliated Hospital of China Medical University, No, 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China.
出版信息
Lipids Health Dis. 2014 Mar 25;13:55. doi: 10.1186/1476-511X-13-55.
BACKGROUND
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in the pathophysiology of atherosclerosis and thrombosis. This study is aimed at evaluating the potential association of 3'-UTR-C188T and G501C in LOX-1 gene with cerebral infarction.
METHODS
A total of 386 patients with cerebral infarction and 386 healthy controls were included in the study, which were unrelated Chinese Han population in the Liaoning Province of northern China. The single nucleotide polymorphisms, 3'-UTR-C188T and G501C, were analyzed by polymerase chain reaction-ligation detection reaction method.
RESULTS
The frequencies of CC + GC genotype, GC genotype and C allele of G501C in the patients with cerebral infarction were significantly higher than those in the controls (P < 0.01, P < 0.01, P = 0.04, respectively). The correlation still remained after adjusting for confounding risk factors of cerebral infarction. In addition, no significant association was observed between 3'-UTR-C188T and cerebral infarction.
CONCLUSIONS
The study indicated that the G501C variant in LOX-1 gene may be associated with susceptibility to cerebral infarction, independent of other common risk factors, in northern Chinese Han population.
背景
凝集素样氧化型低密度脂蛋白受体-1（LOX-1）在动脉粥样硬化和血栓形成的病理生理学中发挥重要作用。本研究旨在评估 LOX-1 基因 3'-UTR-C188T 和 G501C 多态性与脑梗死的潜在关联。
方法
本研究共纳入 386 例脑梗死患者和 386 例健康对照者，均为中国北方辽宁省的无关汉族人群。采用聚合酶链反应-连接酶检测反应法分析单核苷酸多态性 3'-UTR-C188T 和 G501C。
结果
脑梗死患者中 G501C 的 CC+GC 基因型、GC 基因型和 C 等位基因的频率明显高于对照组（P<0.01，P<0.01，P=0.04，分别）。校正脑梗死的混杂危险因素后，相关性仍然存在。此外，3'-UTR-C188T 与脑梗死之间未见明显相关性。
结论
本研究表明，LOX-1 基因的 G501C 变异可能与北方汉族人群脑梗死的易感性有关，独立于其他常见的危险因素。
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