一种新型B细胞特异性增强子的剖析
Anatomy of a new B-cell-specific enhancer.
作者信息
Koch W, Benoist C, Mathis D
机构信息
Laboratoire de Génétique Moléculaire des Eucaryotes, Centre National de la Recherche Scientifique, Strasbourg, France.
出版信息
Mol Cell Biol. 1989 Jan;9(1):303-11. doi: 10.1128/mcb.9.1.303-311.1989.
Abstract
The major histocompatibility complex class II molecules, like the immunoglobulins, are prominent B-lymphocyte markers. Herein, we describe a B-cell-specific enhancer associated with the murine class II gene, Ek alpha. This enhancer has a complex anatomy that suggests interactions between remotely spaced elements. Of particular interest is the finding that two CCAAT boxes spaced one kilobase apart are important for enhancer activity. Somewhat surprisingly, the E alpha and immunoglobulin enhancers seem to show little resemblance.
摘要
主要组织相容性复合体II类分子与免疫球蛋白一样，是显著的B淋巴细胞标志物。在此，我们描述了一个与小鼠II类基因Ek alpha相关的B细胞特异性增强子。该增强子具有复杂的结构，提示远距离元件之间存在相互作用。特别有趣的是，发现两个相隔1千碱基的CCAAT框对增强子活性很重要。有点令人惊讶的是，Eα增强子和免疫球蛋白增强子似乎没有多少相似之处。
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