Gisondi P, Amerio P, Amoroso G F, Antonucci V A, Bardazzi F, Buongiorno M R, Bruni P, Campanati A, Caproni M, Carlesimo M, Carrera C G, Cianchino G, Cimmino G, Costanzo A, Cozzani E, Dapavo P, D'amico D, De Simone C, Del Giglio M, Di Nuzzo S, Gai F, Galluccio A G, Goffredo A, Gualdi G, Guarneri C, Kokelj F, Lasagni C, Loconsole F, Longo V, Malagoli P, Miracapillo A, Mugheddu C, Parodi A, Pellegrino M, Peserico A, Piaserico S, Pistone G, Potenza C, Plumari A, Stingeni L, Strippoli D, Travaglino M, Girolomoni G
Clinica Dermatologica, Università degli Studi di Verona, Verona, Italia -
G Ital Dermatol Venereol. 2013 Dec;148(6 Suppl 1):1-10.
The aim of this study was to provide practical recommendations for optimizing the use of conventional and biological systemic treatments for moderate-severe chronic plaque psoriasis, particularly in case of transitioning and switching.
A total number of 147 dermatologists from 33 different countries including Italy achieved consensus in providing practical recommendations for the use of conventional and biological treatments for moderate to severe psoriasis based on systematic literature review and/or expert opinion.
In general, the continuous treatment regimen should be preferred in order to achieve a complete and long-term control of psoriasis. However, the treatment could be stopped or the dose reduced in case of complete disease clearance. A conventional drug could be associated to biological treatment in selected cases. Transitioning and/or switching could be considered in case of inefficacy or intolerance. A period of wash up is required if transitioning or switching is due to safety issues.
This study provides practical suggestions for the optimal use of conventional and biological treatments for chronic plaque psoriasis.
本研究旨在为优化中重度慢性斑块状银屑病的传统和生物系统治疗的使用提供实用建议，特别是在过渡和转换治疗的情况下。
来自包括意大利在内的33个不同国家的总共147名皮肤科医生，基于系统的文献综述和/或专家意见，就中重度银屑病的传统和生物治疗的使用达成了提供实用建议的共识。
一般而言，为了实现对银屑病的完全和长期控制，应优先选择连续治疗方案。然而，在疾病完全清除的情况下，可以停止治疗或减少剂量。在某些特定情况下，传统药物可与生物治疗联合使用。在治疗无效或不耐受的情况下，可以考虑过渡和/或转换治疗。如果因安全问题进行过渡或转换治疗，则需要一段洗脱期。
本研究为慢性斑块状银屑病传统和生物治疗的最佳使用提供了实用建议。
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