Nicola N A
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Behring Inst Mitt. 1988 Aug(83):207-15.
Granulocyte colony-stimulating factor (G-CSF) is a strongly conserved glycoprotein which induces the survival, proliferation and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The actions of G-CSF are mediated through a small number of specific cellular receptors which are induced to internalize and accumulate within the cell after binding of G-CSF at 37 degrees C. G-CSF receptors can be lost from the cell surface not only by binding G-CSF, but indirectly by other factors including GM-CSF, Multi-CSF, bacterial lipopolysaccharides, chemotactic peptides and phorbol esters, depending on cell type. Possible relationships of these processes to the mechanism of action of G-CSF are discussed.
粒细胞集落刺激因子（G-CSF）是一种高度保守的糖蛋白，可诱导嗜中性粒细胞前体细胞的存活、增殖和分化，并在功能上激活成熟血液中的中性粒细胞。在集落刺激因子家族中，G-CSF是白血病髓系细胞系向粒细胞和巨噬细胞终末分化的最有效诱导剂。G-CSF的作用是通过少数特定的细胞受体介导的，这些受体在37℃下与G-CSF结合后被诱导内化并在细胞内积累。G-CSF受体不仅可以通过与G-CSF结合而从细胞表面丢失，还可以根据细胞类型被其他因素间接丢失，这些因素包括GM-CSF、多能集落刺激因子、细菌脂多糖、趋化肽和佛波酯。文中讨论了这些过程与G-CSF作用机制的可能关系。
