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血管手术后的麻醉类型与术后谵妄

Type of anesthesia and postoperative delirium after vascular surgery.

作者信息

Ellard Louise, Katznelson Rita, Wasowicz Marcin, Ashworth Alan, Carroll Jo, Lindsay Thomas, Djaiani George

机构信息

Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, Canada.

Division of Vascular Surgery, University of Toronto, Toronto, Canada.

出版信息

J Cardiothorac Vasc Anesth. 2014 Jun;28(3):458-61. doi: 10.1053/j.jvca.2013.12.003. Epub 2014 Mar 27.

Abstract

OBJECTIVE

The purpose of this study was to investigate the association between general (GA), regional (RA), and local (LA) anesthetic techniques with respect to the development of delirium after vascular surgery. The authors hypothesized that patients undergoing GA for vascular surgery would have a higher incidence of postoperative delirium. The role of LA with respect to postoperative delirium in vascular surgery patients previously has not been reported.

DESIGN

Retrospective review.

SETTING

Tertiary referral center, university hospital.

PARTICIPANTS

500 patients undergoing vascular surgical procedures.

INTERVENTIONS

Based on the chosen anesthetic technique, all patients were divided into GA, RA, and LA groups, respectively. Exclusion criteria were patients with preoperative dementia or abnormal level of consciousness, patients undergoing open abdominal aneurysm repair surgery, and patients undergoing carotid endarterectomy. All anesthetic techniques were conducted according to routine institutional practices. Patients in both the RA and LA groups received intravenous sedation.

MEASUREMENTS AND MAIN RESULTS

Three hundred ninety-six (79%) patients received GA, 73 (15%) RA, and 31 (6%) LA. The overall incidence of delirium was 19.4% and rates were similar among the 3 groups, with 73 (18.4%) patients in the GA group, 17 (23.2%) in the RA group, and 7 (22.5%) in the LA group (p = 0.56). Patients in the LA group were more likely to have emergency surgery and also had a higher incidence of previous cerebrovascular accidents or transient ischemic attacks. There was no significant difference with respect to either onset or duration of delirium among the 3 groups. Median length of hospital stay and in-hospital mortality were similar among the 3 groups.

CONCLUSIONS

Delirium rates after vascular surgery were similar with local, regional, or general anesthesia techniques. The presence of risk factors for the development of postoperative delirium should not influence the type of anesthesia provided.

摘要

目的

本研究旨在探讨全身麻醉(GA)、区域麻醉(RA)和局部麻醉(LA)技术与血管手术后谵妄发生之间的关联。作者假设接受血管手术全身麻醉的患者术后谵妄发生率更高。此前尚未报道局部麻醉在血管手术患者术后谵妄方面的作用。

设计

回顾性研究。

地点

三级转诊中心,大学医院。

参与者

500例行血管外科手术的患者。

干预措施

根据所选麻醉技术,将所有患者分别分为全身麻醉组、区域麻醉组和局部麻醉组。排除标准为术前患有痴呆或意识水平异常的患者、接受开放性腹主动脉瘤修复手术的患者以及接受颈动脉内膜切除术的患者。所有麻醉技术均按照机构常规操作进行。区域麻醉组和局部麻醉组的患者均接受静脉镇静。

测量指标及主要结果

396例(79%)患者接受全身麻醉,73例(15%)接受区域麻醉,31例(6%)接受局部麻醉。谵妄的总体发生率为19.4%,三组发生率相似,全身麻醉组73例(18.4%),区域麻醉组17例(23.2%),局部麻醉组7例(22.5%)(p = 0.56)。局部麻醉组患者更有可能接受急诊手术,且既往脑血管意外或短暂性脑缺血发作的发生率也更高。三组在谵妄的发作或持续时间方面无显著差异。三组的中位住院时间和院内死亡率相似。

结论

血管手术后谵妄发生率在局部、区域或全身麻醉技术下相似。术后谵妄发生的危险因素的存在不应影响所提供的麻醉类型。

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