阿尔茨海默病患者脑脊液和血浆中胰岛素样生长因子-II及其结合蛋白水平的变化：一项观察性研究
Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study.
作者信息
Hertze Joakim, Nägga Katarina, Minthon Lennart, Hansson Oskar
机构信息
Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
出版信息
BMC Neurol. 2014 Apr 1;14:64. doi: 10.1186/1471-2377-14-64.
BACKGROUND
The Insulin-like Growth Factor (IGF)-related system is implicated in neuroregeneration and cell repair, as well as regulating lifespan. IGF-II, one component of this system, has also been found to affect memory functions in a rat model. In this study we explored changes in the IGF-related system in patients with Alzheimer's disease (AD), including changes in IGF-II levels.
METHODS
We measured blood plasma and cerebrospinal fluid (CSF) levels of IGF-I, IGF-II, IGFBP-2 and IGFBP-3 in 72 healthy controls and 92 patients with AD.
RESULTS
We found significantly lower blood plasma levels of IGF-II and IGFBP-3 in patients with AD, compared with controls. The levels of IGF-II and IGFBP-2 were significantly elevated in the CSF from patients with AD. We also found correlations between established CSF biomarkers for AD (tau and P-tau) and components of the IGF system.
CONCLUSIONS
CSF and blood plasma levels of IGF-II and some of its binding proteins are changed in patients with AD. Further investigation into this area may unravel important clues to the nature of this disease.
背景
胰岛素样生长因子（IGF）相关系统与神经再生、细胞修复以及寿命调节有关。该系统的一个组成部分IGF-II，在大鼠模型中也被发现会影响记忆功能。在本研究中，我们探讨了阿尔茨海默病（AD）患者IGF相关系统的变化，包括IGF-II水平的变化。
方法
我们测量了72名健康对照者和92名AD患者血浆和脑脊液（CSF）中IGF-I、IGF-II、IGFBP-2和IGFBP-3的水平。
结果
我们发现，与对照组相比，AD患者血浆中IGF-II和IGFBP-3水平显著降低。AD患者脑脊液中IGF-II和IGFBP-2水平显著升高。我们还发现AD既定的脑脊液生物标志物（tau和P-tau）与IGF系统各成分之间存在相关性。
结论
AD患者脑脊液和血浆中IGF-II及其一些结合蛋白水平发生了变化。对该领域的进一步研究可能会揭示这种疾病本质的重要线索。
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