反义RNA：其在基因调控中的功能与应用——综述

Antisense RNA: its functions and applications in gene regulation--a review.

作者信息

Inouye M

机构信息

Department of Biochemistry, Robert Wood Johnson Medical School at Rutgers, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.

出版信息

Gene. 1988 Dec 10;72(1-2):25-34. doi: 10.1016/0378-1119(88)90124-2.

DOI:10.1016/0378-1119(88)90124-2

PMID:2468565

Abstract

All known antisense RNAs existing in nature are described. Of 11 natural antisense RNAs, nine function at the level of transcription and two at the level of DNA replication. On the basis of their inhibitory mechanisms they can be separated into three classes. From what can be found in the naturally occurring antisense RNAs, strategies in designing artificial antisense RNAs for gene expression are proposed, and applications and potential problems discussed.

摘要

文中描述了自然界中所有已知的反义RNA。在11种天然反义RNA中，9种在转录水平发挥作用，2种在DNA复制水平发挥作用。根据其抑制机制，它们可分为三类。基于天然存在的反义RNA中的发现，提出了设计用于基因表达的人工反义RNA的策略，并讨论了其应用和潜在问题。