Masini E, Giannella E, Palmerani B, Pistelli A, Gambassi F, Mannaioni P F
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Int Arch Allergy Appl Immunol. 1989;88(1-2):134-5. doi: 10.1159/000234766.
In isolated rat serosal mast cells, studies with the fluorescent Ca2+ indicator, quin 2, and with [3H]-myoinositol to label endogenous polyphosphoinositides have established that an increase in cytosol Ca2+ levels was obligatory for histamine release by free radicals. No substantial breakdown of phosphatidylinositol and related polyphosphoinositides was associated with generation of the Ca2+ signal and histamine release, suggesting that the release of histamine by free radicals entails different pathways than the calcium-mobilizing receptors linked to polyphosphoinositides as second messengers.
在分离的大鼠浆膜肥大细胞中，使用荧光钙指示剂喹啉2以及[3H] - 肌醇标记内源性多磷酸肌醇进行的研究表明，细胞质钙水平的升高是自由基释放组胺所必需的。磷脂酰肌醇和相关多磷酸肌醇的大量分解与钙信号的产生和组胺释放无关，这表明自由基释放组胺所涉及的途径与以多磷酸肌醇作为第二信使的钙动员受体所涉及的途径不同。
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