Scharf J, von Kummer R, Back T, Reich H, Machens G, Wildemann B
Neurologische Universitätsklinik, Heidelberg, Federal Republic of Germany.
J Neurol. 1989 Mar;236(3):164-7. doi: 10.1007/BF00314334.
The effect of haemodilution with Ringer's solution, hydroxyethyl starch (HAES) 200/0.5 10% and dextran 40 on cerebral blood flow (CBF) was measured in ten cats by means of the hydrogen clearance technique. As expected from theoretical considerations the haemodilution effect was short and not significant with Ringer's solution, but was 25% with HAES and 35% with dextrane 40. The corresponding rise in CBF was significant in both the latter but not with Ringer's solution. CBF was similarly highly correlated with diminution of haematocrit (Hct). The different effects of the substances on CBF could all be explained by their different effects on the Hct. Data analysis, together with recent literature, suggests that the dominating factor determining CBF was the O2-transport capacity, which in these experiments was in close relation to Hct. The results support the assumption that the increase of CBF by haemodilution is caused by a regulatory mechanism and not by a change of rheological parameters.
采用氢清除技术，在10只猫身上测量了用林格氏液、羟乙基淀粉（HAES）200/0.5 10%和右旋糖酐40进行血液稀释对脑血流量（CBF）的影响。正如理论推测的那样，林格氏液的血液稀释作用短暂且不显著，但羟乙基淀粉的作用为25%，右旋糖酐40的作用为35%。后两者引起的CBF相应升高具有显著性，而林格氏液则不然。CBF同样与血细胞比容（Hct）的降低高度相关。这些物质对CBF的不同作用都可以用它们对Hct的不同作用来解释。数据分析以及近期文献表明，决定CBF的主要因素是氧运输能力，在这些实验中，氧运输能力与Hct密切相关。结果支持这样的假设，即血液稀释引起的CBF增加是由一种调节机制导致的，而非流变学参数的改变。
