Wibowo Bogi P, Wibawa I D N, Utsumi Takako, Mustika Syifa, Amin Mochamad, Wahyuni Rury M, Kurniawan Hendra, Hendrayana Agus, Setiawan Poernomo B, Yamani Laura N, Yano Yoshihiko, Hotta Hak, Hayashi Yoshitake, Lusida Maria I
Department of Microbiology, School of Medicine, Airlangga University, Surabaya, East Java, Indonesia Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, East Java, Indonesia.
Division of Gastroenterohepatology, Department of Internal Medicine, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia.
J Clin Microbiol. 2014 Jun;52(6):2193-5. doi: 10.1128/JCM.00768-14. Epub 2014 Apr 2.
This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.
本研究表明,印度尼西亚慢性丙型肝炎患者(大多为爪哇族)大多感染丙型肝炎病毒(HCV)1型;然而,他们主要携带白细胞介素28B(IL-28B)单核苷酸多态性(SNP)的主要基因型(rs12979860 CC、rs11881222 TT、rs8103142 AA和rs8099917 TT),并且他们大多对聚乙二醇干扰素/利巴韦林治疗实现了持续病毒学应答。