Moulinier-Anzola Jeanette, De-Araujo Lucinda, Korbei Barbara
Department of Applied Genetics and Cell Biology; University of Natural Resources and Life Sciences; Vienna (BOKU), Austria.
Plant Signal Behav. 2014;9(4):e28667. doi: 10.4161/psb.28667. Epub 2014 Apr 3.
A strict control of abundance and localization of plasma membrane proteins is essential for plants to be able to respond quickly and accurately to a changing environment. The proteins responsible for the initial recognition and concentration of ubiquitinated plasma membrane proteins destined for degradation, are well characterized in mammals and yeast, (1) yet no clear orthologs were found in plants. (2) Recently, we have identified a family of proteins in higher plants, which function in vacuolar targeting and subsequent degradation of ubiquitinated plasma membrane proteins (3,4) termed TOM1-like (TOL) proteins.
严格控制质膜蛋白的丰度和定位对于植物能够快速准确地应对不断变化的环境至关重要。负责识别和浓缩注定要降解的泛素化质膜蛋白的初始蛋白质,在哺乳动物和酵母中已有充分研究,(1)但在植物中尚未发现明确的直系同源物。(2)最近,我们在高等植物中鉴定出一类蛋白质,它们在泛素化质膜蛋白的液泡靶向和后续降解中发挥作用(3,4),称为类TOM1(TOL)蛋白。