Lamberti Monica, Giovane Giancarlo, Garzillo Elpidio M, Avino Franca, Feola Antonia, Porto Stefania, Tombolini Vincenzo, Di Domenico Marina
Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine, Area of Occupational Medicine, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy.
National Institute for the Study and Treatment of Cancer, Foundation "G. Pascale", Via Mariano Semmola, 80131 Napoli, Italy.
Biomed Res Int. 2014;2014:240642. doi: 10.1155/2014/240642. Epub 2014 Feb 19.
Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.
心脏毒性是细胞毒性药物的一种重要副作用，对于治疗期间的患者以及在抗增殖药物操作阶段接触药物的工作人员而言，都可能是长期发病的一个风险因素。在体外和体内研究的心脏毒性机制主要涉及自由基的形成，进而导致氧化应激，引发心肌细胞凋亡或免疫反应，但其他机制可能在抗增殖药物诱导的心脏毒性中发挥作用。实际上，一些新型细胞毒性药物如曲妥珠单抗和环戊烯基胞嘧啶也表现出心脏毒性作用。在本报告中，我们讨论了使用动物模型评估的抗增殖药物诱导心脏毒性的不同机制。
