Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Cell Stem Cell. 2014 Apr 3;14(4):421-2. doi: 10.1016/j.stem.2014.03.008.
Recent studies (Shlush et al., 2014; Corces-Zimmerman et al., 2014) have demonstrated that leukemias develop from hematopoietic stem cells that acquire preleukemic mutations, allowing clonal expansion and subsequent acquisition of mutations leading to cancer. Preleukemic cells survive chemotherapy and serve as reservoirs for disease, generating new clones and leading to relapse.
最近的研究（Shlush 等人，2014 年；Corces-Zimmerman 等人，2014 年）表明，白血病是由获得前白血病突变的造血干细胞发展而来的，这些突变允许克隆扩张，随后获得导致癌症的突变。前白血病细胞能在化疗中存活下来，并作为疾病的储库，产生新的克隆，导致疾病复发。
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