移植。T 细胞耗竭——平衡急性排斥反应和癌症风险。
Transplantation. T-cell depletion--balancing acute rejection and cancer risk.
机构信息
Division of Nephrology, David Geffen School of Medicine at UCLA, 7-155 Factor Building, 10833 Le Conte Boulevard, Los Angeles, CA 90095-1689, USA.
出版信息
Nat Rev Nephrol. 2014 Jun;10(6):301-2. doi: 10.1038/nrneph.2014.61. Epub 2014 Apr 8.
PMID:24709843
Abstract
The authors of a new study suggest that the proinflammatory state of acute rejection combined with the use of T-cell-depleting antibody therapy might explain the increased risk of cancer after kidney transplantation. However, their findings do not fully support this conclusion; use of T-cell-depleting antibodies alone is likely to increase cancer risk.
摘要
一项新研究的作者提出，急性排斥反应的促炎状态加上 T 细胞耗竭抗体治疗的应用，可能解释了肾移植后癌症风险增加的原因。然而，他们的发现并不完全支持这一结论；单独使用 T 细胞耗竭抗体可能会增加癌症风险。
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