血清干扰素-α是抗黑色素瘤分化相关基因5（MDA5）抗体阳性皮肌炎患者的一种有用生物标志物。
Serum interferon-α is a useful biomarker in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis.
作者信息
Horai Yoshiro, Koga Tomohiro, Fujikawa Keita, Takatani Ayuko, Nishino Ayako, Nakashima Yoshikazu, Suzuki Takahisa, Kawashiri Shin-ya, Iwamoto Naoki, Ichinose Kunihiro, Tamai Mami, Nakamura Hideki, Ida Hiroaki, Kakugawa Tomoyuki, Sakamoto Noriho, Ishimatsu Yuji, Mukae Hiroshi, Hamaguchi Yasuhito, Fujimoto Manabu, Kuwana Masataka, Origuchi Tomoki, Kohno Shigeru, Kawakami Atsushi
机构信息
Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
出版信息
Mod Rheumatol. 2015 Jan;25(1):85-9. doi: 10.3109/14397595.2014.900843. Epub 2014 Apr 9.
OBJECTIVE
We have tried to clarify the clinical importance of the measurement of serum type-I interferon (IFN) in patients with anti-melanoma differentiation-associated gene 5 Ab (MDA5 Ab)-positive dermatomyositis (DM).
METHODS
We studied 30 patients with DM: 10 were anti-MDA5 Ab-positive and 20 were anti-MDA5 Ab-negative. At each patient's initial visit, serum IFN-α, IFN-β, interleukin 18 (IL-18), ferritin, and the titer of anti-MDA5 Ab were measured using enzyme-linked immunosorbent assays (ELISAs). The associations between the IFNs and with the other variables were examined.
RESULTS
Rapidly progressive interstitial lung disease (RPILD) was confirmed in 10 patients, most of whom were complicated in the anti-MDA5 Ab-positive DM patients. The presence of clinically amyopathic dermatomyositis (CADM) as well as the serum concentrations of IFN-α and ferritin was significantly higher in the anti-MDA5 Ab-positive DM patients. Serum concentration of IL-18 did not differ between anti-MDA5 Ab-positive and anti-MDA5 Ab-negative groups; however, a positive correlation was found between IFN-α and IL-18 in the anti-MDA5 Ab-positive DM patients (r = 0.8139, p = 0.0146).
CONCLUSION
Serum IFN-α can be used as a useful biomarker in patients with anti-MDA5 Ab-positive DM, which may reflect the presence of RPILD.
目的
我们试图阐明在抗黑色素瘤分化相关基因5抗体（MDA5 Ab）阳性皮肌炎（DM）患者中检测血清I型干扰素（IFN）的临床重要性。
方法
我们研究了30例DM患者：10例抗MDA5 Ab阳性，20例抗MDA5 Ab阴性。在每位患者初次就诊时，使用酶联免疫吸附测定（ELISA）检测血清IFN-α、IFN-β、白细胞介素18（IL-18）、铁蛋白和抗MDA5 Ab滴度。研究了IFN与其他变量之间的关联。
结果
10例患者确诊为快速进展性间质性肺病（RPILD），其中大多数合并于抗MDA5 Ab阳性的DM患者。抗MDA5 Ab阳性的DM患者中临床无肌病性皮肌炎（CADM）的存在以及IFN-α和铁蛋白的血清浓度显著更高。抗MDA5 Ab阳性组和抗MDA5 Ab阴性组之间的IL-18血清浓度无差异；然而，在抗MDA5 Ab阳性的DM患者中，IFN-α与IL-18之间存在正相关（r = 0.8139，p = 0.0146）。
结论
血清IFN-α可作为抗MDA5 Ab阳性DM患者的有用生物标志物，这可能反映RPILD的存在。
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