Ricciardelli Gabriella, Ceccuzzi Roberto, Raneri Marco, Scalisi Antonino, Bianchi Paolo E
Department of Ophthalmology, IRCCS Foundation S. Matteo Hospital, University of Pavia, Pavia - Italy.
Eur J Ophthalmol. 2014 Sep-Oct;24(5):793-6. doi: 10.5301/ejo.5000464. Epub 2014 Apr 4.
Amniotic membrane (AM), or amnion, is a thin membrane on the inner side of the fetal placenta; it completely surrounds the embryo/fetus and delimits the amniotic cavity, which is filled by amniotic liquid. In recent years, the structure and function of the amnion have been investigated due to its pluripotent properties, which are an attractive source for tissue transplantation and reconstructive surgery. The pioneering use of AM in skin transplantation by Davis dates back to 1910; in 1913, Sabella and Stern employed it in the treatment of burns and superficial scars. Certain characteristics make the AM ideally suited to its application in ocular surface reconstruction. It can be easily obtained and its availability is nearly unlimited. We report a case of AM transplantation to treat ocular surface abnormality.
A 28-year-old man came to our attention for persistent foreign body feeling and pain in his right eye. Because of progressive clinical worsening, we decided to perform surgical apposition of AM.
Clinical and instrumental follow-up was conducted with periodic complete checkups. At 1 year follow-up, best-corrected visual acuity was 4/10.
Characteristics of AM make it potentially useful to treat ocular surface abnormalities.
羊膜是胎儿胎盘内侧的一层薄膜，它完全包裹着胚胎/胎儿，并界定充满羊水的羊膜腔。近年来，由于羊膜具有多能特性，其结构和功能受到了研究，这使其成为组织移植和重建手术的一个有吸引力的来源。戴维斯于1910年率先将羊膜用于皮肤移植；1913年，萨贝拉和斯特恩将其用于治疗烧伤和浅表瘢痕。某些特性使羊膜非常适合应用于眼表重建。它很容易获取且几乎可以无限量供应。我们报告一例羊膜移植治疗眼表异常的病例。
一名28岁男性因右眼持续异物感和疼痛前来就诊。由于临床症状逐渐恶化，我们决定进行羊膜手术贴合。
通过定期全面检查进行临床和仪器随访。在1年的随访中，最佳矫正视力为4/10。
羊膜的特性使其在治疗眼表异常方面具有潜在用途。
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