Withrington P G, de Nucci G, Vane J R
Department of Pharmacology, St Bartholomew's Hospital Medical College, London, England.
J Cardiovasc Pharmacol. 1989;13 Suppl 5:S209-10. doi: 10.1097/00005344-198900135-00060.
Endothelin-1 (ET-1; 1 pmol-1 nmol) was injected intra-arterially into the canine hepatic artery perfused, in situ, with arterial blood. The characteristic arterial vascular response to ET-1 was biphasic consisting of an initial increase in flow (vasodilatation) of short duration followed by a prolonged reduction in flow (vasoconstriction). The hepatic portal circuit was perfused at a constant flow with blood derived from the mesenteric circuit. Hepatic portal inflow pressure was continuously recorded. ET-1 injected intraportally increased the portal perfusion pressure indicating an increase in portal inflow resistance. This portal vasoconstrictor response to ET-1 was of much longer duration than that previously observed with other vasoactive agents in this vascular territory.
将内皮素-1（ET-1；1皮摩尔至1纳摩尔）经动脉内注射到在体原位用动脉血灌注的犬肝动脉中。ET-1引起的典型动脉血管反应呈双相性，先是短暂的血流增加（血管舒张），随后是血流持续减少（血管收缩）。肝门静脉循环以恒定流量灌注来自肠系膜循环的血液。持续记录肝门静脉流入压。经门静脉注射ET-1可增加门静脉灌注压，表明门静脉流入阻力增加。ET-1引起的这种门静脉血管收缩反应的持续时间比此前在此血管区域观察到的其他血管活性药物引起的反应持续时间长得多。
