内皮素-1的抗炎作用
Anti-inflammatory effects of endothelin-1.
作者信息
Chander C L, Moore A R, Desa F M, Howat D W, Willoughby D A
机构信息
Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London, England.
出版信息
J Cardiovasc Pharmacol. 1989;13 Suppl 5:S218-9. doi: 10.1097/00005344-198900135-00064.
Abstract
Endothelin-1 (ET-1), when injected intradermally in rats concurrently with FMLP, did not suppress cell accumulation 6 h later. In view of the fact that ET-1 can antagonize mediators of increased vascular permeability, it is proposed that this is further evidence that fluid and cell accumulation at an inflammatory site are separate processes.
摘要
内皮素 -1（ET -1）在大鼠皮内与FMLP同时注射时，6小时后并未抑制细胞聚集。鉴于ET -1可拮抗血管通透性增加的介质，有人提出这进一步证明了炎症部位的液体和细胞聚集是独立的过程。
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