Shimamoto K, Nakagawa M, Fukuyama S, Ura N, Murakami H, Yonekura S, Iwakura M, Yamaguchi Y, Ise T, Saitoh S
Second Department of Internal Medicine, Sapporo Medical College, Japan.
J Cardiovasc Pharmacol. 1989;13 Suppl 6:S59-62.
To clarify the effects of norepinephrine and angiotension II (Ang II) on plasma atrial natriuretic peptide (ANP), both pressor substances were infused into normal volunteers, and plasma ANP levels and venous return were determined. When norepinephrine infusion elevated mean arterial pressure by 15 mm Hg, a transient increase of plasma ANP was observed. However, Ang II infusion showed no effect on plasma ANP levels, even though it also elevated arterial pressure. Superior vena cava flow and left atrial area, which were determined echocardiographically as the index of venous return, increased in the norepinephrine infusion study. However, in the study of Ang II infusion, there was no significant change in either superior vena cava flow or left atrial area. From these results, it was concluded that increased left atrial volume due to increased venous return is the major factor inducing ANP release in norepinephrine infusion.
为阐明去甲肾上腺素和血管紧张素II（Ang II）对血浆心钠素（ANP）的影响，将这两种升压物质注入正常志愿者体内，并测定血浆ANP水平和静脉回流量。当注入去甲肾上腺素使平均动脉压升高15 mmHg时，观察到血浆ANP短暂升高。然而，尽管注入Ang II也使动脉压升高，但对血浆ANP水平无影响。在去甲肾上腺素注入研究中，经超声心动图测定作为静脉回流指标的上腔静脉血流量和左心房面积增加。然而，在Ang II注入研究中，上腔静脉血流量和左心房面积均无显著变化。从这些结果得出结论，在去甲肾上腺素注入过程中，静脉回流量增加导致左心房容积增大是诱导ANP释放的主要因素。
