干扰素-β相关性疼痛性三叉神经神经病复发归因于多发性硬化斑块。

Interferon beta-associated recurrence of painful trigeminal neuropathy attributed to a multiple sclerosis plaque.

机构信息

Department of Neurology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

出版信息

J Headache Pain. 2014 Apr 17;15(1):21. doi: 10.1186/1129-2377-15-21.

DOI:10.1186/1129-2377-15-21

PMID:24742132

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4005472/

Abstract

We report the case of a 49-year-old woman with painful trigeminal neuropathy in the right maxillary division attributed to a multiple sclerosis plaque as the presenting symptom of multiple sclerosis. The patient was initially treated with intravenous corticosteroids and was pain free on pregabalin for six months. She was then started on an immunomodulatory treatment and coinciding with the up-titration of interferon beta-1a, she experienced recurrence of painful trigeminal neuropathy as well as weekly migraine attacks. Worsening of primary headache disorders by interferon treatment has been previously reported. Our case suggests that treatment with interferon beta may also exacerbate symptomatic trigeminal neuralgia in multiple sclerosis.

摘要

我们报告了一例 49 岁女性，其右侧上颌支的三叉神经痛归因于多发性硬化斑块，这是多发性硬化症的首发症状。患者最初接受了静脉注射皮质类固醇治疗，同时服用普瑞巴林治疗，疼痛缓解了六个月。随后，她开始接受免疫调节治疗，在干扰素 β-1a 加量的同时，她经历了三叉神经痛的复发和每周偏头痛发作。先前有报道称，干扰素治疗会加重原发性头痛障碍。我们的病例表明，干扰素 β 治疗也可能加重多发性硬化症的症状性三叉神经痛。