第三个T细胞受体β链可变区基因编码对Mls-1a基因产物的反应性。
A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products.
作者信息
Happ M P, Woodland D L, Palmer E
机构信息
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
出版信息
Proc Natl Acad Sci U S A. 1989 Aug;86(16):6293-6. doi: 10.1073/pnas.86.16.6293.
Abstract
Using a quantitative RNA hybridization method, we have identified a third murine T-cell receptor beta-chain variable (V) region gene, V beta 9, that engenders recognition of Mls-1a gene products. V beta 9-expressing T cells are clonally deleted from the periphery of mice that carry the Mls-1a allele, and the fine specificity of V beta 9+ hybridomas suggests that V beta 6-, V beta 8.1-, and V beta 9-encoded T-cell receptors may recognize a similar antigenic epitope. Comparison of these three protein sequences identifies two residues that may be important in determining this recognition specificity.
摘要
运用定量RNA杂交方法，我们鉴定出了第三个小鼠T细胞受体β链可变（V）区基因Vβ9，它能引发对Mls-1a基因产物的识别。表达Vβ9的T细胞在携带Mls-1a等位基因的小鼠外周被克隆清除，Vβ9 +杂交瘤的精细特异性表明，Vβ6 -、Vβ8.1 -和Vβ9编码的T细胞受体可能识别相似的抗原表位。对这三种蛋白质序列的比较确定了两个在决定这种识别特异性方面可能很重要的残基。
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